National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more
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TLDR
In this article, the authors proposed a new clinical scoring system (0-3) that describes the extent and severity of chronic graft-versus-host disease for each organ or site at any given time, taking functional impact into account.About:
This article is published in Biology of Blood and Marrow Transplantation.The article was published on 2015-03-01 and is currently open access. It has received 2883 citations till now. The article focuses on the topics: Graft-versus-host disease & Transplantation.read more
Citations
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Journal ArticleDOI
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more
TL;DR: The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence, and focuses attention on the causes of organ-specific abnormalities to chronic GVHD.
Journal ArticleDOI
Graft-versus-host disease
TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
Journal ArticleDOI
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
John Koreth,Ken-ichi Matsuoka,Haesook T. Kim,Sean McDonough,Bhavjot Bindra,Edwin P. Alyea,Philippe Armand,Corey Cutler,Vincent T. Ho,Nathaniel S. Treister,Don C. Bienfang,Sashank Prasad,Dmitrios Tzachanis,Robin Joyce,David Avigan,Joseph H. Antin,Jerome Ritz,Robert J. Soiffer +17 more
TL;DR: Daily low-dose interleukin-2 was safely administered in patients with active chronic GVHD that was refractory to glucocorticoid therapy and was associated with preferential, sustained Treg cell expansion in vivo and amelioration of the manifestations of chronic GvHD in a substantial proportion of patients.
Journal ArticleDOI
Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors
Claudio Anasetti,Brent R. Logan,Stephanie J. Lee,Edmund K. Waller,Daniel J. Weisdorf,John R. Wingard,Corey Cutler,Peter Westervelt,Ann E. Woolfrey,Stephen Couban,Gerhard Ehninger,Laura Johnston,Richard T. Maziarz,Michael A. Pulsipher,David L. Porter,Shin Mineishi,John M. McCarty,Shakila P. Khan,Paolo Anderlini,William I. Bensinger,Susan F. Leitman,Scott D. Rowley,Christopher Bredeson,Shelly L. Carter,Mary M. Horowitz,Dennis L. Confer +25 more
TL;DR: A phase 3, multicenter, randomized trial of transplantation of peripheral-blood stem cells versus bone marrow from unrelated donors did not detect significant survival differences, and exploratory analyses of secondary end points indicated that peripheral- Blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduceThe risk of chronic GVHD.
Journal ArticleDOI
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells.
Piotr Trzonkowski,Maria Bieniaszewska,Jolanta Juścińska,Anita Dobyszuk,Adam Krzystyniak,Natalia Marek,Jolanta Myśliwska,Andrzej Hellmann +7 more
TL;DR: The therapy allowed for significant alleviation of the symptoms and reduction of pharmacologic immunosuppression in the case of chronic GvHD, while in the cases of grade IV acute Gv HD it only transiently improved the condition, for the longest time within all Immunosuppressants used nonetheless.
References
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Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 seattle patients
Howard M. Shulman,Keith M. Sullivan,Paul L. Weiden,George B. McDonald,Gary E. Striker,George E. Sale,Robert C. Hackman,Tsoi Ms,Rainer Storb,E. Donnall Thomas +9 more
TL;DR: Three patients had limited chronic GVHD with relatively favorable prognosis characterized by localized skin involvement and/or hepatic disease without chronic aggressive histology, but most patients, however, had extensive disease with a progressive course.
Journal ArticleDOI
Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources.
Vanderson Rocha,John E. Wagner,Kathleen A. Sobocinski,John P. Klein,Mei-Jie Zhang,Mary M. Horowitz,Eliane Gluckman +6 more
TL;DR: Recipients of cord-blood transplants from HLA-identical siblings have a lower incidence of acute and chronic GVHD than recipients of bone marrow transplant from H LA-Identical siblings.
Journal ArticleDOI
Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age
Craig Kollman,Craig W. S. Howe,Claudio Anasetti,Joseph H. Antin,Stella M. Davies,Alexandra H. Filipovich,J Hegland,Naynesh Kamani,Nancy A. Kernan,Roberta King,Voravit Ratanatharathorn,Daniel J. Weisdorf,Dennis L. Confer +12 more
TL;DR: Age should be considered when selecting among comparably HLA-matched volunteer donors and the use of younger donors may lower the incidence of GVHD and improve survival after bone marrow transplantation.
Journal ArticleDOI
Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation.
Marco Mielcarek,Paul J. Martin,Wendy M. Leisenring,Mary E.D. Flowers,David G. Maloney,Brenda M. Sandmaier,Michael B. Maris,Rainer Storb +7 more
TL;DR: The results show that nonablative HSCT is associated with a syndrome of acute GVHD occurring after day 100 in many patients, and should be taken into consideration in the design of prospective studies comparing GV HD resulting from the two types of transplantation procedures.
Journal ArticleDOI
Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse
Stephanie J. Lee,John P. Klein,A. John Barrett,Olle Ringdén,Joseph H. Antin,Jean-Yves Cahn,Matthew Carabasi,Robert Peter Gale,Sergio Giralt,Gregory A. Hale,Osman Ilhan,Philip L. McCarthy,Gérard Socié,Leo F. Verdonck,Daniel J. Weisdorf,Mary M. Horowitz +15 more
TL;DR: A grading system predictive for survival was developed by using data from 1827 HLA-matched sibling allotransplant recipients reported to the International Bone Marrow Transplant Registry, and Karnofsky performance score, diarrhea, weight loss, and cutaneous and oral involvement were found to be independent prognostic variables, from which a grading scheme was generated.
Related Papers (5)
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more