M
Mary E. Harper
Researcher at National Institutes of Health
Publications - 21
Citations - 4093
Mary E. Harper is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 17, co-authored 21 publications receiving 4074 citations. Previous affiliations of Mary E. Harper include North Shore-LIJ Health System.
Papers
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Journal ArticleDOI
HTLV-III infection in brains of children and adults with AIDS encephalopathy
George M. Shaw,Mary E. Harper,Beatrice H. Hahn,Leon G. Epstein,D. Carleton Gajdusek,Richard W. Price,Bradford A. Navia,Carol K. Petito,Carl O'Hara,Jerome E. Groopman,Eun Sook Cho,James M. Oleske,Flossie Wong-Staal,Robert C. Gallo +13 more
TL;DR: Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS.
Journal ArticleDOI
Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization
TL;DR: It is demonstrated that HTLV-III expression in lymph node and peripheral blood is very low in vivo and the lymph node hyperplasia observed in HT LV-III-associated lymphadenopathy is not directly due to proliferation of HTLV -III-infected lymphocytes.
Journal ArticleDOI
The trans-activator gene of HTLV-III is essential for virus replication
Amanda G. Fisher,Mark B. Feinberg,Steven F. Josephs,Mary E. Harper,L. M. Marselle,Gregory R. Reyes,Matthew A. Gonda,Anna Aldovini,Debouk C,Robert C. Gallo +9 more
TL;DR: It is shown that derivatives of a biologically competent molecular clone of HTLV-III, in which the tat-Ill gene is deleted or the normal splicing abrogated, failed to produce or expressed unusually low levels of virus, respectively, when transfected into T-cell cultures.
Journal ArticleDOI
Multiple sclerosis and human T-cell lymphotropic retroviruses.
Hilary Koprowski,Elaine Defreitas,Mary E. Harper,Magnhild Sandberg-Wollheim,William A. Sheremata,Marjorie Robert-Guroff,Carl Saxinger,Mark B. Feinberg,Flossie Wong-Staal,Robert C. Gallo +9 more
TL;DR: A combination of different types of data suggests that some multiple sclerosis patients respond immunologically to, and have cerebrospinal T cells containing, a retrovirus that is related to, but distinct from, the three types of human T-cell lymphotropic viruses.
Book ChapterDOI
Molecular Biology of Human T-Lymphotropic Retroviruses
Flossie Wong-Staal,Lee Ratner,George M. Shaw,Beatrice H. Hahn,Mary E. Harper,Genoveffa Franchini,Robert C. Gallo +6 more
TL;DR: HTLV-III frequently infects the brain of acquired immunodeficiency syndrome patients who suffer from central nervous system disorders and poses the problem of crossing the blood-brain barrier in therapy strategies to eradicate the virus, which provides a basis for new classification of retroviruses.