M
Mary J. Cismowski
Researcher at Nationwide Children's Hospital
Publications - 38
Citations - 1485
Mary J. Cismowski is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Heterotrimeric G protein & Signal transduction. The author has an hindex of 19, co-authored 38 publications receiving 1347 citations. Previous affiliations of Mary J. Cismowski include The Research Institute at Nationwide Children's Hospital & Neurocrine Biosciences.
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Journal ArticleDOI
Receptor-independent activators of heterotrimeric g-protein signaling pathways
Aya Takesono,Mary J. Cismowski,Catalina Ribas,Michael L. Bernard,Peter Chung,Starr Hazard,Emir Duzic,Stephen M. Lanier +7 more
TL;DR: AGS proteins provide unexpected mechanisms for input to heterotrimeric G-protein signaling pathways and may also serve as novel binding partners for Gα and Gβγ that allow the subunits to subserve functions that do not require initialheterotrimer formation.
Journal ArticleDOI
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.
Mary J. Cismowski,Aya Takesono,Chienling Ma,Jeffrey S. Lizano,Xiaobing Xie,Hans Fuernkranz,Stephen M. Lanier,Emir Duzic +7 more
TL;DR: A cDNA product identified from the inhibitor screen encodes a previously identified regulator of G-protein signaling, human RGS5, and appears to function by facilitating guanosine triphosphate (GTP) exchange on the heterotrimeric Gα.
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Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration.
Mary J. Cismowski,Chienling Ma,Catalina Ribas,Xiaobing Xie,Michael Spruyt,Jeffrey S. Lizano,Stephen M. Lanier,Emir Duzic +7 more
TL;DR: The in vivo and in vitro properties of AGS1 are consistent with it functioning as a direct guanine nucleotide exchange factor for Gαi/Gαo heterotrimeric signaling pathways, which presents a unique mechanism for signal integration via heterOTrimeric G-protein signaling pathways.
Journal ArticleDOI
Receptor-independent activators of heterotrimeric G-proteins.
TL;DR: Using a functional screen based upon the pheromone response pathway in Saccharomyces cerevisiae, three proteins were identified, AGS1-3 (for Activators of G-protein Signalling), that activated heterotrimeric G- protein signalling pathways in the absence of a typical receptor.
Journal ArticleDOI
Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome.
Aaron J. Trask,Aaron J. Trask,Paige S. Katz,Paige S. Katz,Amy P. Kelly,Maarten L. Galantowicz,Mary J. Cismowski,Mary J. Cismowski,T. Aaron West,Zachary P. Neeb,Zachary C. Berwick,Adam G. Goodwill,Mouhamad Alloosh,Johnathan D. Tune,Michael Sturek,Pamela A. Lucchesi,Pamela A. Lucchesi +16 more
TL;DR: The data suggest that MetS causes hypertrophic inward remodeling of CRMs and capillary rarefaction, which contribute to decreased coronary flow and myocardial ischemia.