Mary Kaileh

TL;DR: The results indicate that pure WA or WA-enriched WS extracts can be considered as a novel class of NFκB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.

TL;DR: This work shows that BCR signaling induced production of the nonclassical transcription factor NF-κB pathway substrate p100, which is required for transmission of BR3 signals and thus B cell survival, and identifies a molecular mechanism for the reliance of primary B cells on continuous BR3 and B CR signaling.

TL;DR: Whereas Withania somnifera extract demonstrated the strongest NFkappaB-inhibitory activity, other extracts derived from Laurus nobilis, Psidium guajava and Foeniculum vulgare M. (Umbiliferrae) also revealed immunomodulatory NFKappaB activities, and are good candidates for further activity-monitored fractionation to identify active constituents.

TL;DR: This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A.

TL;DR: X stimulates the proapoptotic arm of the UPR in ex vivo CLL cells, suggesting that ER stress may play an important role during X-induced apoptosis.