M
Mary Lynne Hedley
Researcher at Eisai
Publications - 4
Citations - 106
Mary Lynne Hedley is an academic researcher from Eisai. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 4, co-authored 4 publications receiving 94 citations.
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Immunization with a poly (lactide co-glycolide) encapsulated plasmid DNA expressing antigenic regions of HPV 16 and 18 results in an increase in the precursor frequency of T cells that respond to epitopes from HPV 16, 18, 6 and 11
Mark Matijevic,Mary Lynne Hedley,Robert G. Urban,Roman M. Chicz,Christa Lajoie,Thomas M. Luby +5 more
TL;DR: Data demonstrate that treatment with amolimogene elicits T cell responses to HPV 16, 18, 6 and 11, and T cells primed and expanded in vitro with an HPV 18 peptide demonstrated cross-reactivity to the corresponding HPV 11 peptide.
Journal ArticleDOI
Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization
Christine M. Barbon,Min Yang,Gregory D. Wands,Radha Ramesh,Barbara S. Slusher,Mary Lynne Hedley,Thomas M. Luby +6 more
TL;DR: The synergistic activity of pharmacologic T(reg) depletion with cyclophosphamide is reported on quantitatively and qualitatively increasing T cell responses to a known human tumor-associated antigen.
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In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization.
Christine M. Barbon,Lisa Baker,Christa Lajoie,Urban Ramstedt,Mary Lynne Hedley,Thomas M. Luby +5 more
TL;DR: Increased immunogenicity observed with the combination of PLG-encapsulated plasmid DNA microparticle with EPT was caused by an increase in the recruitment of antigen presenting cells which mediated a more robust T cell response than observed with immunization alone.
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Inhibition of NF-κB activity by plasmid expressed αMSH peptide
TL;DR: Plasmid-based vectors were created that constitutively express the immunomodulatory peptide αMSH and the activity of these vectors provides tools and the impetus for testing the constructs in several animal models of chronic inflammation.