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Mary Sara McPeek
Researcher at University of Chicago
Publications - 59
Citations - 3452
Mary Sara McPeek is an academic researcher from University of Chicago. The author has contributed to research in topics: Population & Association mapping. The author has an hindex of 28, co-authored 59 publications receiving 3329 citations. Previous affiliations of Mary Sara McPeek include University of California, Berkeley & University of Illinois at Chicago.
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Journal ArticleDOI
Statistical Tests for Detection of Misspecified Relationships by Use of Genome-Screen Data
Mary Sara McPeek,Lei Sun +1 more
TL;DR: Two new test statistics-conditional expected IBD (EIBD) and adjusted IBS (AIBS)-designed to retain the simplicity of IBS while increasing power by taking into account chance sharing are proposed.
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Assessment of Linkage Disequilibrium by the Decay of Haplotype Sharing, with Application to Fine-Scale Genetic Mapping
TL;DR: Simulations show that the DHS method works extremely well both for estimation of LD and for fine mapping, and it is applied to published data sets for cystic fibrosis and progressive myoclonus epilepsy.
Journal ArticleDOI
Case-Control Association Testing with Related Individuals: A More Powerful Quasi-Likelihood Score Test
TL;DR: A novel test, the MQLS test, is proposed, which represents an overall, and in many cases, substantial, improvement in power over previous tests, while retaining a computational simplicity that makes it useful in genomewide association studies in arbitrary pedigrees.
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The Genetic Dissection of Complex Traits in a Founder Population
TL;DR: The present study demonstrates the feasibility of genomewide association studies for QTL mapping among the Hutterites, however, even in this young founder population that has extensive linkage disequilibrium, map densities <<5 cM may be required to detect all major QTLs.
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ROADTRIPS: Case-Control Association Testing with Partially or Completely Unknown Population and Pedigree Structure
TL;DR: The proposed ROADTRIPS method, which uses a covariance matrix estimated from genome-screen data to correct for unknown population and pedigree structure while maintaining high power, provides a substantial improvement over existing methods in terms of power and type 1 error.