Masaharu Miyajima

TL;DR: The results suggest that proper selection of rate-controlling agents based on their physicochemical properties (such as swelling ability and solubility) is important in designing WMGs with desired dissolution profiles.

TL;DR: A computerized optimizing technique based on a response surface methodology was developed to study the scale-up problem in the manufacturing of granules, and it was found that a universal optimal formulation unaffected by manufacturing scale could be obtained by minimizing the integrated optimization function.

TL;DR: Computer optimization technique applied to the simultaneous optimization of wet granulation process by a high-speed mixer granulator suggested that computer optimization would benefit the wet granulations process even if drug content segregation was involved in the process.

TL;DR: In this paper, a computer optimization technique based on well-designed experiments is applied to optimize the wet granulation process in which an explosive growth of particles is involved, and a universal optimal condition unaffected by manufacturing scale is obtained by the minimization of T(X).

TL;DR: Control of 9-β-arabinofuranosyladenine and ara-A-2',3'-diacetate concentrations in blood from zero-order transdermal delivery systems was achieved using newly designed transder mal patches with rate-limiting membranes using copolymer compositions chosen according to the hydration properties of the membrane.