Showing papers in "International Journal of Pharmaceutics in 1997"

TL;DR: The potential applications of liposomes in drug delivery with examples of formulations approved for clinical use are discussed, and the problems associated with further exploitation of this drug delivery system are discussed.

TL;DR: In vivo studies showed that the CS-coated nanocapsules represent a useful approach for increasing the ocular bioavailability of drugs.

TL;DR: This study characterised a number of gels containing either HEC or Na CMC in terms of their mechanical/textural, viscoelastic and mucoadhesive properties and suggested that the information derived from these methods may be usefully combined to provide a more rational basis for the selection of polymers and their formulation as topical drug delivery systems.

TL;DR: Cytotoxicity towards B16F10 cells and ability to lyse rat erythrocytes was concentration-dependent and varied according to the salt used and polymer molecular weight, and polymers of higher molecular weight of each type were most toxic.

TL;DR: The use and potential of solubility parameters for pharmaceutical dosage form design are reviewed and specific reference is given to the development of the approach, its previous usage and likely future applications.

TL;DR: In this article, solid lipid nanoparticles (SLN) have been prepared from three oil-in-water microemulsions, whose internal phase was constituted of different lipid matrices, and the dispersion media were two aqueous solution of trehalose and Pluronic F68 at 2% besides distilled water.

TL;DR: In this paper, the authors used in-line near infra-red spectroscopy (NIRS) to obtain granule moisture content and particle size change data, allowing modification of process conditions if required and end-point identification.

TL;DR: The sugar trehalose proved to be most effective in preventing particle growth during freezing and thawing and also in the freeze-drying process and the lyophilisate quality is sufficient for formulations less critical to limited particle growth.

TL;DR: In this article, the effects of sample size and number of samples are examined using an alternative characterization technique in which a powder mixture is solidified through infiltration with a polymer solution, sliced, and examined using image analysis.

TL;DR: The physicochemical behavior of colloidal lipid suspensions and lipid o/w emulsions has been studied in this article, where it was observed that recrystallization is associated with an increase in specific interfacial area due to the formation of anisometrical, platelet-like colloidal crystals with structured surfaces.

TL;DR: In this article, the authors developed a direct compression method for the preparation, using mannitol and camphor, of a meclizine tablet with high porosity which dissolves rapidly in saliva.

TL;DR: In this article, stable self-emulsifying water-in-oil (w/o) microemulsions of extremely small particle size (5-30 nm) and consisting of an oil, a blend of a low and high HLB surfactants and an aqueous phase, have been developed using commercially available and pharmaceutically acceptable components.

TL;DR: This study shows that some proteins are able to endure the harsh procedures of formulation by high pressure homogenisation, making possible the use of SLN as antigen carriers for vaccine delivery.

TL;DR: Upon the study of crosslinking rate, DXR-loaded nanoparticles showed a greater number of free amino groups than the unloaded ones, which should be due to a competition between the amino group of DXR and the amino groups of the gelatin chains during the cross-linking process.

TL;DR: The influence of different formulation and process parameters on the characteristics of lyophilized oral dosage forms was investigated and the strength of the tablets was enhanced by using higher maltodextrin concentrations and the integrity and strength depended on the xanthan gum concentration and the tablet dimensions.

TL;DR: In this article, the apparent ionization constants (psKa) of 25 molecules, based on 431 separate potentiometric titrations, were determined in methanol/water mixtures of 15-65 wt% methanoline content.

TL;DR: It is concluded from this study that chitosans are potent absorption enhancers for peptide drugs, but that they are unable to prevent degradation from proteolytic enzymes.

TL;DR: Dry powders and their delivery devices are an alternative to pressurized metered-dose inhalers for the administration of aerosols to the lungs and deposition was found to be highly dependent on the dry powder formulation.

TL;DR: Results demonstrated that surface coating liposomes with PEG or mucin gained resistance against digestion by bile salts and increased the stability in the GI tract.

TL;DR: In this paper, it was shown that the two theoretical cosolvency models, i.e., the excess free energy, EFE, and the combined nearly ideal binary solvent/Redlich-Kister, CNIBS/R-K, despite different appearances could be converted to a general single model, GSM, using some appropriate substitutions and rearrangements.

TL;DR: In this paper, the importance of the nature of two solvents used in a patented method for obtaining aqueous dispersions of polymers is discussed, and the influence of the dielectric constant (ϵ) of the final dispersant medium (a mixture of acetone and water after dispersion of organic phase with aaqueous phase) is also discussed.

TL;DR: In this article, the influence of the degree of hydrolyzation and polymerization of poly(vinylalcohol) (PVA) used as an emulsion stabilizer was investigated on the preparation of poly ( dl -lactide-co-glycolide) (PLGA) nanoparticles with the spontaneous emulsification solvent diffusion process.

TL;DR: In this paper, an alternative micronization technique using the aerosol solvent extraction system (ASES) was investigated, where several steroids, some for systemic and some for administration by inhalation, were dissolved in an organic solvent and sprayed into supercritical carbon dioxide.

TL;DR: In this paper, an analysis of the results suggested that enhanced penetration across human skin from supersaturated solutions of piroxicam may occur as a result of the antinucleating ability of the intercellular lipids of the stratum corneum.

TL;DR: Analysis of their in vitro antiproliferative activity on cultured human leukemic K562 cells demonstrated that liposomes, micellar solutions and microemulsion containing camptothecin exert similar or slightly enhanced effect as compared to that shown by the free drug.

TL;DR: In this article, the authors used polyvinylpyrrolidone (PVP) and polypropylmethylcellulose (HPMC) as water-soluble polymers for RS-8359 from supersaturated solutions.

TL;DR: This study evaluated the accuracy of the dose and the theoretically respirable fraction emitted from commonly used dry powder inhalers and found that most products were found to emit a fine particle dose of 20–30% of total emitted dose at 60 l min −1 .

TL;DR: These studies with a common, numerically important, colonic bacterium indicate that the reduction of an azopolymer may be influenced by the chemical nature of the azo compound used as cross-linker.

TL;DR: In this paper, a new method for obtaining the model constants of the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) equation via least square analysis has been presented.

TL;DR: Ciprofloxacin hexahydrate has been prepared and its crystal structure has been determined by X-ray crystallography as mentioned in this paper, the molecule is in the zwitterionic form in solid state, the carboxylic proton being present at terminal piperazine nitrogen atom (N(74)).