Journal ArticleDOI
Dissolution Mechanism of Diclofenac Sodium from Wax Matrix Granules
TLDR
The results suggest that proper selection of rate-controlling agents based on their physicochemical properties (such as swelling ability and solubility) is important in designing WMGs with desired dissolution profiles.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1997-08-01. It has received 93 citations till now.read more
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Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal Article
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: In this paper, the physicochemical factors involved in the in vitro release of medroxyprogesterone acetate (MPA) a water-insoluble steroid embedded in a silicone rubber matrix was based upon a model system which considered the matric boundary diffusion layer.
Journal Article
Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery.
TL;DR: The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical nature of drug.
Journal ArticleDOI
Applications of hot-melt extrusion for drug delivery.
TL;DR: The range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration are reviewed.
Journal ArticleDOI
Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion.
TL;DR: Analysis of the hot-melt extruded granules showed better drug content uniformity among granules of different size ranges compared with high-shear melt granules, resulting in a more reproducible drug release from the corresponding tablets.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.
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Kinetics of drug release from hydrogel matrices
TL;DR: The kinetics of drug release from hydrogel matrices will be examined both experimentally and theoretically and special emphasis will be placed on the effect of local drug concentration on the swelling behavior ofhydrogel drug carriers.