M
Masahiro Fujimuro
Researcher at Kyoto Pharmaceutical University
Publications - 104
Citations - 5728
Masahiro Fujimuro is an academic researcher from Kyoto Pharmaceutical University. The author has contributed to research in topics: Primary effusion lymphoma & Kaposi's sarcoma-associated herpesvirus. The author has an hindex of 36, co-authored 93 publications receiving 5300 citations. Previous affiliations of Masahiro Fujimuro include Johns Hopkins University & University of Tokyo.
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Journal ArticleDOI
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Makoto R. Hara,Nishant Agrawal,Sangwon F. Kim,Matthew B. Cascio,Masahiro Fujimuro,Yuji Ozeki,Masaaki Takahashi,Jaime H. Cheah,Stephanie Tankou,Lynda D. Hester,Christopher D. Ferris,S. Diane Hayward,Solomon H. Snyder,Akira Sawa +13 more
TL;DR: A signalling pathway in which nitric oxide generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis, which is prevented by NO deletion is reported.
Journal ArticleDOI
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
Byoung-Il Bae,Hong Xu,Shuichi Igarashi,Masahiro Fujimuro,Nishant Agrawal,Yoichi Taya,S. Diane Hayward,Timothy H. Moran,Craig Montell,Christopher A. Ross,Solomon H. Snyder,Akira Sawa +11 more
TL;DR: Evidence for a specific role of p53 in the mitochondria-associated cellular dysfunction and behavioral abnormalities of Huntington's disease is presented and findings suggest that p53 links nuclear and mitochondrial pathologies characteristic of HD.
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A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency
Masahiro Fujimuro,Frederick Y. Wu,Colette Aprhys,Henry Kajumbula,David B. Young,Gary S. Hayward,S. Diane Hayward +6 more
TL;DR: The Kaposi's sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, and it is found that β-catenin is overexpressed in both PEL cells and KS tissue.
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Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins
TL;DR: A simple method was developed for the efficient preparation of polyubiquitinated proteins which are degraded by the 26 S proteasome in an ATP‐dependent manner, which enabled us to produce ten monoclonal antibodies that recognized the multi‐ubiqu itin chains of the polyubiqueinated proteins, but not free ubiquitin or the protein moieties.
Journal ArticleDOI
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Sifang Zhou,Masahiro Fujimuro,James J. Hsieh,Lin Chen,Alison Miyamoto,Gerry Weinmaster,S. Diane Hayward +6 more
TL;DR: The results suggest a model in which NotchIC activates responsive promoters by competing with the SMRT-corepressor complex for contacts on both CBF1 and SKIP.