Showing papers by "Masakazu Toi published in 1993"
TL;DR: Breakdown analysis stratified by nodal status showed that the vessel density was a significant prognostic indicator in node‐negative and node‐positive patients and Multivariate analysis indicated that the vessels density is an independent prognostic indicators in primary breast‐cancer patients.
Abstract: Clinical importance of tumor angiogenesis, especially its significance as a prognostic indicator, was examined in 125 primary breast-cancer patients The grade of neovascularization was assessed by the vessel density which was obtained by immunocytochemical staining for factor VIII antigen Postoperative survey demonstrated that the vessel density is a statistically significant predictor of relapse-free survival (median follow-up period: 62 months) Patients with over 100 counts of factor-VIII antigen-positive cells per 200 x field in the most active areas of neovascularization showed significantly poorer prognosis than those with less than 100 counts The prognostic value of the vessel density was also confirmed by another evaluation method using immunocytochemical staining to CD-31 which is a platelet/endothelial cell adhesion molecule A significant difference in relapse-free survival rate was shown between patients having higher counts of CD-31 positive cells and those having lower counts Breakdown analysis stratified by nodal status showed that the vessel density was a significant prognostic indicator in node-negative and node-positive patients Multivariate analysis indicated that the vessel density is an independent prognostic indicator in primary breast-cancer patients
317 citations
TL;DR: Results indicate that radicicol might be a potential drug for treating different angiogenesis-dependent diseases, such as solid tumors, psoriasis, rheumatoid arthritis, and diabetic retinopathy.
45 citations
Journal Article•
TL;DR: An increased stabilization of 5-fluorodeoxyuridine monophosphate (FdUMP)-thymidylate synthase(TS)-folate ternary complex with the addition of [6S]LV was confirmed and an increase of total TS activity was also found.
Abstract: The influence of the addition of [6S] leucovorin (LV) to 5-fluorouracil (5-FU) preoperative chemotherapy was examined in patients with surgically resectable breast cancer who had had no prior treatment. The patients underwent one of the following three treatments at their will: (1) 5-FU 50 mg/m 2 administered by an IV bolus; (2) [6S]LV 250 mg/m 2 infused intravenously over two hours, with 5-FU 500 mg/m 2 as an IV bolus at the midpoint of [6S]LV infusion, (3) no drug treatment. Tumors were resected 24 hours after the dose of 5-FU with or without [6S]LV
5 citations
TL;DR: A 27-year-old woman developed a left breast mass 2 years after chemotherapy and radiation for nodular sclerosing stage IIB Hodgkin's disease and remains well without any evidence of recurrent Hodgkins disease or breast cancer.
Abstract: An unusual case of primary squamous cell carcinoma of the breast occurring after cured Hodgkin's disease is reported herein. A 27-year-old woman developed a left breast mass 2 years after chemotherapy and radiation for nodular sclerosing stage IIB Hodgkin's disease. Excisional biopsy revealed squamous cell carcinoma of the breast and a modified radical mastectomy was performed, however, no metastasis was found in the axillary nodes. She received etoposide, mitomycin-C, and doxifluoridine as adjuvant chemotherapy, and remains well without any evidence of recurrent Hodgkin's disease or breast cancer. To our knowledge, this is the first reported case of primary squamous cell carcinoma of the breast associated with Hodgkin's disease. The risk of patients treated for Hodgkin's disease developing breast cancer as a second malignant neoplasm is discussed following the report of this case.
4 citations