M
Masaru Takayanagi
Researcher at University of California, San Diego
Publications - 7
Citations - 360
Masaru Takayanagi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Total synthesis & Glycopeptide antibiotic. The author has an hindex of 5, co-authored 7 publications receiving 355 citations. Previous affiliations of Masaru Takayanagi include Scripps Research Institute.
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Total Synthesis of Vancomycin Aglycon—Part 3: Final Stages
Kyriacos C. Nicolaou,Masaru Takayanagi,Nareshkumar F. Jain,S. Natarajan,Alexandros E. Koumbis,Toshikazu Bando,J. M. Ramanjulu +6 more
TL;DR: A triazene-based synthetic strategy for the construction of the complex biaryl ethers and a Suzuki coupling reaction were the key steps in the synthesis of precursor 1 of the aglycon of vancomycin, which already contains the complete skeleton of the target compound.
Journal ArticleDOI
Total Synthesis of Vancomycin Aglycon-Part 2: Synthesis of Amino Acids 1-3 and Construction of the AB-COD-DOE Ring Skeleton.
Kyriacos C. Nicolaou,Nareshkumar F. Jain,S. Natarajan,Robert Hughes,Michael E. Solomon,Hui Li,J. M. Ramanjulu,Masaru Takayanagi,Alexandros E. Koumbis,Toshikazu Bando +9 more
TL;DR: A triazene-based synthetic strategy for the construction of the complex biaryl ethers and a Suzuki coupling reaction were the key steps in the synthesis of precursor 1 of the aglycon of vancomycin, which already contains the complete skeleton of the target compound.
Journal ArticleDOI
Total synthesis of vancomycin. part 3 : synthesis of the aglycon
Kyriacos C. Nicolaou,Alexandros E. Koumbis,Masaru Takayanagi,Swaminathan Natarajan,Nareshkumar F. Jain,Toshikazu Bando,Hui Li,Robert Hughes +7 more
TL;DR: A number of valuable new synthetic strategies, such as triazene-driven biaryl ether synthesis, have been developed during the total synthesis of vancomycin this paper, which was then assembled to the appropriate peptide fragments.
Journal ArticleDOI
Totalsynthese des Vancomycin‐Aglycons – Teil 3: letzte Schritte
Kyriacos C. Nicolaou,Masaru Takayanagi,Nareshkumar F. Jain,Swaminathan Natarajan,Alexandros E. Koumbis,Toshikazu Bando,Joshi M. Ramanjulu +6 more
Journal ArticleDOI
Totalsynthese des Vancomycin-Aglycons – Teil 1: Synthese der Aminosäuren 4–7 und Aufbau des AB-COD-Ringgerüsts
Kyriacos C. Nicolaou,Swaminathan Natarajan,Hui Li,Nareshkumar F. Jain,Robert Hughes,Michael E. Solomon,Joshi M. Ramanjulu,Christopher N. Boddy,Masaru Takayanagi +8 more
TL;DR: Eine Triazeneinheit als Schlusselstruktur fur die Synthese komplexer Biarylether and eine Suzuki-Kupplung waren die wesentlichen Merkmale beim Aufbau der Vorstufe 1 des Aglycons von Vancomycin, die bereits das vollstandige Grundgerust der Zielverbindung enthalt; dabei wurde die Triazen-Methode im Zuge dieser Synthetse ent