N
Nareshkumar F. Jain
Researcher at Johnson & Johnson Pharmaceutical Research and Development
Publications - 64
Citations - 2022
Nareshkumar F. Jain is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Enantioselective synthesis & Total synthesis. The author has an hindex of 22, co-authored 64 publications receiving 1834 citations. Previous affiliations of Nareshkumar F. Jain include University of California, San Diego & Boston University.
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Current ADC Linker Chemistry
TL;DR: Site-specific conjugations may involve genetic engineering of the mAb to introduce discrete, available cysteines or non-natural amino acids with an orthogonally-reactive functional group handle such as an aldehyde, ketone, azido, or alkynyl tag to increase the homogeneity of ADCs.
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Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
Steven Seaman,Zhongyu Zhu,Saurabh Saha,Xiaoyan M. Zhang,Mi Young Yang,Mary Beth Hilton,Karen Morris,Christopher S. Szot,Holly Morris,Deborah A. Swing,Lino Tessarollo,Sean W. Smith,Sylvia Degrado,Dmitry Borkin,Nareshkumar F. Jain,Julia Scheiermann,Yang Feng,Yanping Wang,Jinyu Li,Dean Welsch,Decrescenzo Gary A,Amit Chaudhary,Enrique Zudaire,Kimberly D. Klarmann,Jonathan R. Keller,Dimiter S. Dimitrov,Brad St. Croix +26 more
TL;DR: It is demonstrated that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
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Total Synthesis of Vancomycin
Kyriacos C. Nicolaou,Helen J. Mitchell,Nareshkumar F. Jain,Nicolas Winssinger,Robert Hughes,Toshikazu Bando +5 more
TL;DR: The fine-tuning of the protecting groups and the glycosidation conditions were the key to the successful coupling of the carbohydrate units and vancomycin aglycon in the last steps of the total synthesis of vancomYcin 1.
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Total Synthesis of Vancomycin—Part 2: Retrosynthetic Analysis, Synthesis of Amino Acid Building Blocks and Strategy Evaluations
Kyriacos C. Nicolaou,Christopher N. Boddy,Hui Li,Alexandros E. Koumbis,Robert Hughes,Swaminathan Natarajan,Nareshkumar F. Jain,Joshi M. Ramanjulu,Stefan Bräse,Michael E. Solomon +9 more
TL;DR: A number of valuable new synthetic strategies, such as triazene-driven biaryl ether synthesis, have been developed during the total synthesis of vancomycin this article, which was then assembled to the appropriate peptide fragments.
Journal ArticleDOI
Total Synthesis of Vancomycin Aglycon—Part 3: Final Stages
Kyriacos C. Nicolaou,Masaru Takayanagi,Nareshkumar F. Jain,S. Natarajan,Alexandros E. Koumbis,Toshikazu Bando,J. M. Ramanjulu +6 more
TL;DR: A triazene-based synthetic strategy for the construction of the complex biaryl ethers and a Suzuki coupling reaction were the key steps in the synthesis of precursor 1 of the aglycon of vancomycin, which already contains the complete skeleton of the target compound.