Masashi Mizuguchi

TL;DR: Various syndromes of acute encephalopathy are reviewed by classifying them into three major categories, caused by metabolic derangement, which includes Reye‐like syndrome, hemorrhagic shock and encephalitis syndrome, and acute necrotizing encephalopathic syndrome.

TL;DR: Based on the characteristic combination of clinical and pathological findings, acute necrotising encephalopathy of childhood can be distinguished from previously known encephalopathies, including Reye's syndrome.

TL;DR: A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire, finding that Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathic syndromes.

TL;DR: The clinical, radiological and pathological features of acute necrotizing encephalopathy of childhood, a disease entity established recently, are described and its distinction from clinically similar conditions and from pathologically related conditions, such as the Leigh and Wernicke encephalopathies are discussed.

TL;DR: It is shown that mammalian target of rapamycin inhibitors may be useful for the pharmacological treatment of autism spectrum disorder associated with tuberous sclerosis complex and other conditions that result from dysregulated mammalian targets ofRapamycin signalling.