Journal ArticleDOI
Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes.
Ai Hoshino,Makiko Saitoh,Akira Oka,Akihisa Okumura,Masaya Kubota,Yoshiaki Saito,Jun-ichi Takanashi,Shinichi Hirose,Takanori Yamagata,Hideo Yamanouchi,Masashi Mizuguchi +10 more
TLDR
A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire, finding that Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathic syndromes.Abstract:
A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire. A total of 983 cases reportedly had acute encephalopathy during the past 3 years, 2007-2010. Among the pathogens of the preceding infection, influenza virus was the most common, followed by human herpesvirus-6 (HHV-6) and rotavirus. Among syndromes of acute encephalopathy, acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was the most frequent, followed by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS), acute necrotizing encephalopathy (ANE) and hemorrhagic shock and encephalopathy syndrome (HSES). Influenza virus was strongly associated with ANE and MERS, HHV-6 with AESD, and rotavirus with MERS. Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathy. Neurologic sequelae were common in AESD and ANE, but were absent in MERS.read more
Citations
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Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
TL;DR: From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.
Journal ArticleDOI
Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder.
TL;DR: The recurrent and familial forms of ANE were found to be incompletely autosomal-dominant and the missense mutations in the gene encoding the nuclear pore protein Ran Binding Protein 2 (RANBP2) were identified.
Journal ArticleDOI
Neurological Manifestations of Influenza Infection in Children and Adults: Results of a National British Surveillance Study
Anu Goenka,Benedict D Michael,Elizabeth Ledger,Ian J Hart,Michael Absoud,Gabriel Chow,James B. Lilleker,Michael P. Lunn,David McKee,Deirdre Peake,Karen Pysden,Mark Roberts,Enitan D. Carrol,Ming K. Lim,Shivaram Avula,Tom Solomon,Rachel Kneen +16 more
TL;DR: This surveillance study described a cohort of adults and children with neurological manifestations of influenza in adults andChildren in the United Kingdom from February 2011, with the majority of cases due to H1N1.
Journal ArticleDOI
Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy
TL;DR: Treatment with early systemic immune modulators (corticosteroids and/or intravenous immunoglobulin) as soon as possible may reduce aberrant immune responses in the potential stage of ARDS.
Journal ArticleDOI
Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing
Masanori Sato,Makoto Kuroda,Masashi Kasai,Hikoro Matsui,Tetsuhiro Fukuyama,Harutaka Katano,Keiko Tanaka-Taya +6 more
TL;DR: Additional evidence showing human astroviruses are important infectious agents, regardless of their clades, involving the central nervous system in immunocompromised hosts is presented.
References
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Journal ArticleDOI
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion
Hiroko Tada,Jun-ichi Takanashi,A. J. Barkovich,H. Oba,Masayuki Maeda,Hirokazu Tsukahara,Motomasa Suzuki,Toshiyuki Yamamoto,Taro Shimono,Takashi Ichiyama,Toshiaki Taoka,O. Sohma,H. Yoshikawa,Yoichi Kohno +13 more
TL;DR: In this article, the splenium of the corpus callosum (SCC) was ovoid in six patients; it extended irregularly from the center to the lateral portion of SCC in the other eight patients; homogeneously reduced diffusion was seen in all seven patients who underwent diffusion-weighted imaging.
Journal ArticleDOI
Acute encephalopathy associated with influenza and other viral infections
TL;DR: Various syndromes of acute encephalopathy are reviewed by classifying them into three major categories, caused by metabolic derangement, which includes Reye‐like syndrome, hemorrhagic shock and encephalitis syndrome, and acute necrotizing encephalopathic syndrome.
Journal ArticleDOI
In Search of Encephalitis Etiologies: Diagnostic Challenges in the California Encephalitis Project, 1998—2000
Carol A. Glaser,Sabrina Gilliam,David P. Schnurr,Bagher Forghani,Somayeh Honarmand,Nino Khetsuriani,Marc Fischer,C K Cossen,Larry J. Anderson +8 more
TL;DR: The California Encephalitis Project was initiated in June 1998 to identify the causes and characterize the clinical and epidemiologic features of encephalitis in California and the etiology of 208 cases (62%) remained unexplained.
Journal ArticleDOI
Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions.
TL;DR: Based on the characteristic combination of clinical and pathological findings, acute necrotising encephalopathy of childhood can be distinguished from previously known encephalopathies, including Reye's syndrome.
Journal ArticleDOI
Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan
TL;DR: The clinical, radiological and pathological features of acute necrotizing encephalopathy of childhood, a disease entity established recently, are described and its distinction from clinically similar conditions and from pathologically related conditions, such as the Leigh and Wernicke encephalopathies are discussed.