M
Masashi Okuro
Researcher at Kanazawa Medical University
Publications - 57
Citations - 796
Masashi Okuro is an academic researcher from Kanazawa Medical University. The author has contributed to research in topics: Narcolepsy & Diabetes mellitus. The author has an hindex of 13, co-authored 53 publications receiving 644 citations. Previous affiliations of Masashi Okuro include Stanford University & Osaka University.
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Journal ArticleDOI
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait
Luoying Zhang,Arisa Hirano,Pei Ken Hsu,Christopher R. Jones,Noriaki Sakai,Masashi Okuro,Thomas A. McMahon,Maya Yamazaki,Ying Xu,Noriko Saigoh,Kazumasa Saigoh,Shu Ting Lin,Krista Kaasik,Seiji Nishino,Louis J. Ptáček,Ying-Hui Fu +15 more
TL;DR: The identified rare variants in the PERIOD3 gene in persons with both altered sleep behavior and features of seasonal affective disorder recapitulate circadian and mood phenotypes in mouse models, suggesting that PER3 may be a nexus for sleep and mood regulation while fine-tuning these processes to adapt to seasonal changes.
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Hypocretin/orexin and narcolepsy: new basic and clinical insights.
Seiji Nishino,Masashi Okuro,Nozomu Kotorii,Emiko Anegawa,Yuji Ishimaru,Mari Matsumura,Takashi Kanbayashi +6 more
TL;DR: As a large majority of human narcolepsy patients are ligand deficient, hypocretin replacement therapy may be a promising new therapeutic option, and animal experiments using gene therapy and cell transplantations are in progress.
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Increased plasma levels of the soluble form of fas ligand in patients with acute myocardial infarction and unstable angina pectoris
Masumi Shimizu,Keisuke Fukuo,Shigekazu Nagata,Toshimitsu Suhara,Masashi Okuro,Kenshi Fujii,Yorihiko Higashino,Masaki Mogi,Yasuko Hatanaka,Toshio Ogihara +9 more
TL;DR: Activation of the Fas/FasL system may play a pathogenic role in acute myocardial infarction and acute coronary syndromes, as demonstrated by elevated levels of Fas ligand levels in patients with AMI and unstable AP.
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Effects of Paraxanthine and Caffeine on Sleep, Locomotor Activity, and Body Temperature in Orexin/Ataxin-3 Transgenic Narcoleptic Mice
TL;DR: Paraxanthine may be a better wake-promoting agent for hypersomnia associated with neurodegenerative diseases because it is also reported to provide neuroprotection.
Journal ArticleDOI
Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients ☆
Shigeto Morimoto,Kohya Okaishi,Miyuki Onishi,Tomohiro Katsuya,Jin Yang,Masashi Okuro,Shoroku Sakurai,Toshio Onishi,Toshio Ogihara +8 more
TL;DR: The association between the ACE I/D polymorphism and the incidence of pneumonia was assessed during an 8-month period that excluded the winter and the ACE D allele is an independent risk factor for pneumonia in elderly persons.