C
Christopher R. Jones
Researcher at University of Utah
Publications - 39
Citations - 4818
Christopher R. Jones is an academic researcher from University of Utah. The author has contributed to research in topics: Advanced sleep phase disorder & Circadian rhythm. The author has an hindex of 21, co-authored 38 publications receiving 4243 citations. Previous affiliations of Christopher R. Jones include University of Maine.
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Journal ArticleDOI
An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Kong L. Toh,Christopher R. Jones,Yan He,Erik J. Eide,William A. Hinz,David M. Virshup,Louis J. Ptáček,Ying-Hui Fu +7 more
TL;DR: A variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period.
Journal ArticleDOI
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome
Ying Xu,Quasar S Padiath,Robert E. Shapiro,Christopher R. Jones,Susan C. Wu,Noriko Saigoh,Kazumasa Saigoh,Kazumasa Saigoh,Louis J. Ptáček,Louis J. Ptáček,Ying-Hui Fu +10 more
TL;DR: Results show that CKIδ is a central component in the mammalian clock, and suggest that mammalian and fly clocks might have different regulatory mechanisms despite the highly conserved nature of their individual components.
Journal ArticleDOI
Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans
Christopher R. Jones,Scott S. Campbell,Stephanie E. Zone,Fred Cooper,Alison Desano,Patricia J. Murphy,Bryan W. Jones,Laura A. Czajkowski,Louis J. Ptáček +8 more
TL;DR: Three kindreds with a profound phase advance of the sleep–wake, melatonin and temperature rhythms associated with a very short τ represent a well-characterized familial circadian rhythm variant in humans and provide a unique opportunity for genetic analysis of human circadian physiology.
Journal ArticleDOI
Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2
TL;DR: It is shown that phosphorylation at S662 leads to increased PER2 transcription and suggest that phosphORYlation at another site leads to PER2 degradation, demonstrating that CKIdelta can regulate period through PER2 in vivo.
Journal ArticleDOI
The transcriptional repressor DEC2 regulates sleep length in mammals.
Ying He,Christopher R. Jones,Nobuhiro Fujiki,Ying Xu,Bin Guo,Jimmy L. Holder,Moritz J. Rossner,Seiji Nishino,Ying-Hui Fu +8 more
TL;DR: In this paper, the authors identified a mutation in a transcriptional repressor (hDEC2-P385R) associated with a human short sleep phenotype and showed that transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time and sleep deprivation-dependent manner.