M
Masataka Tsuda
Researcher at Hiroshima University
Publications - 32
Citations - 952
Masataka Tsuda is an academic researcher from Hiroshima University. The author has contributed to research in topics: DNA repair & DNA. The author has an hindex of 13, co-authored 32 publications receiving 696 citations. Previous affiliations of Masataka Tsuda include Kyoto University.
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Journal ArticleDOI
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
Kimiyo N. Yamamoto,Shunsuke Kobayashi,Masataka Tsuda,Hitoshi Kurumizaka,Minoru Takata,Koichi Kono,Josef Jiricny,Shunichi Takeda,Kouji Hirota +8 more
TL;DR: It is suggested that ubiquitylated FANCD2 recruits SLX4 to DNA damage sites, where it mediates the resolution of recombination intermediates generated during the processing of ICLs.
Journal ArticleDOI
Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes
Nguyen Ngoc Hoa,Tsubasa Shimizu,Zhong-Wei Zhou,Zhao-Qi Wang,Rajashree A. Deshpande,Tanya T. Paull,Salma Akter,Masataka Tsuda,Ryohei Furuta,Ken Tsutsui,Shunichi Takeda,Hiroyuki Sasanuma +11 more
TL;DR: In this paper, the authors characterized Mre11-deficient (MRE11 −/− ) and nucleasedeficient MRE11 ( MRE 11 −/H129N ) chicken DT40 and human lymphoblast cell lines.
Journal ArticleDOI
Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides
Kaori Kobayashi,Thomas A. Guilliam,Masataka Tsuda,Junpei Yamamoto,Laura J. Bailey,Shigenori Iwai,Shunichi Takeda,Aidan J. Doherty,Kouji Hirota +8 more
TL;DR: Results indicate that PrimPol's repriming activity plays a central role in reinitiating replication downstream from CTNAs and other specific DNA lesions and indicates that its primase, rather than TLS activity, is pivotal for DNA damage tolerance.
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BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.
Hiroyuki Sasanuma,Masataka Tsuda,Masataka Tsuda,Suguru Morimoto,Liton Kumar Saha,Maminur Rahman,Yusuke Kiyooka,Haruna Fujiike,Andrew D. Cherniack,Junji Itou,Elsa Callen Moreu,Masakazu Toi,Shinichiro Nakada,Hisashi Tanaka,Ken Tsutsui,Shintaro Yamada,André Nussenzweig,Shunichi Takeda +17 more
TL;DR: It is shown that BRCA1 promotes MRE11-mediated removal of TOP2 adducts in G1 phase, which plays a critical role in removing pathological TOP2ccs induced by estrogens as well as etoposide throughout the cell cycle.
Journal ArticleDOI
Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA
Suguru Morimoto,Masataka Tsuda,Heeyoun Bunch,Hiroyuki Sasanuma,Caroline A. Austin,Shunichi Takeda +5 more
TL;DR: This review discusses spontaneously arising DSBs caused by the abortive catalysis of TOP2 and summarizes proteins involved in repairing stalled TOP2ccs and discusses the genotoxicity of the sex hormones.