M
Masato Nakagawa
Researcher at Kyoto University
Publications - 87
Citations - 20052
Masato Nakagawa is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 47, co-authored 84 publications receiving 18447 citations. Previous affiliations of Masato Nakagawa include Nagoya University & Nara Institute of Science and Technology.
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Journal ArticleDOI
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Masato Nakagawa,Michiyo Koyanagi,Koji Tanabe,Kazutoshi Takahashi,Tomoko Ichisaka,Takashi Aoi,Keisuke Okita,Yuji Mochiduki,Nanako Takizawa,Shinya Yamanaka +9 more
TL;DR: A modified protocol for the generation of iPS cells that does not require the Myc retrovirus is described and, with this protocol, significantly fewer non-iPS background cells are obtained, and theiPS cells generated were consistently of high quality.
Journal ArticleDOI
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
TL;DR: The production of virus-free iPS cells, albeit from embryonic fibroblasts, addresses a critical safety concern for potential use of i PS cells in regenerative medicine.
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A more efficient method to generate integration-free human iPS cells
Keisuke Okita,Yasuko Matsumura,Yoshiko Sato,Aki Okada,Asuka Morizane,Satoshi Okamoto,Hyenjong Hong,Masato Nakagawa,Koji Tanabe,Ken-ichi Tezuka,Toshiyuki Shibata,Takahiro Kunisada,Masayo Takahashi,Jun Takahashi,Hiroh Saji,Shinya Yamanaka +15 more
TL;DR: A simple method is reported, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors, which may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.
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Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hyenjong Hong,Kazutoshi Takahashi,Tomoko Ichisaka,Takashi Aoi,Osami Kanagawa,Masato Nakagawa,Keisuke Okita,Shinya Yamanaka +7 more
TL;DR: Functional analyses of 34 p53-regulated genes demonstrate that the p53–p21 pathway serves as a barrier not only in tumorigenicity, but also in iPS cell generation in mouse and human fibroblasts.
Journal ArticleDOI
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
Takashi Aoi,Kojiro Yae,Masato Nakagawa,Tomoko Ichisaka,Keisuke Okita,Kazutoshi Takahashi,Tsutomu Chiba,Shinya Yamanaka +7 more
TL;DR: Genetic lineage tracings suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required.