K
Koji Tanabe
Researcher at Kyoto University
Publications - 29
Citations - 29756
Koji Tanabe is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 21, co-authored 27 publications receiving 26457 citations.
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Journal ArticleDOI
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
Journal ArticleDOI
Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: This work generated induced pluripotent stem cells capable of germline transmission from murine somatic cells by transd, and demonstrated the ability of these cells to reprogram into patient-specific and disease-specific stem cells.
Journal ArticleDOI
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Masato Nakagawa,Michiyo Koyanagi,Koji Tanabe,Kazutoshi Takahashi,Tomoko Ichisaka,Takashi Aoi,Keisuke Okita,Yuji Mochiduki,Nanako Takizawa,Shinya Yamanaka +9 more
TL;DR: A modified protocol for the generation of iPS cells that does not require the Myc retrovirus is described and, with this protocol, significantly fewer non-iPS background cells are obtained, and theiPS cells generated were consistently of high quality.
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A more efficient method to generate integration-free human iPS cells
Keisuke Okita,Yasuko Matsumura,Yoshiko Sato,Aki Okada,Asuka Morizane,Satoshi Okamoto,Hyenjong Hong,Masato Nakagawa,Koji Tanabe,Ken-ichi Tezuka,Toshiyuki Shibata,Takahiro Kunisada,Masayo Takahashi,Jun Takahashi,Hiroh Saji,Shinya Yamanaka +15 more
TL;DR: A simple method is reported, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors, which may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.
Journal ArticleDOI
Variation in the safety of induced pluripotent stem cell lines
Kyoko Miura,Yohei Okada,Takashi Aoi,Aki Okada,Kazutoshi Takahashi,Keisuke Okita,Masato Nakagawa,Michiyo Koyanagi,Koji Tanabe,Mari Ohnuki,Daisuke Ogawa,Eiji Ikeda,Hideyuki Okano,Shinya Yamanaka +13 more
TL;DR: This study evaluated the teratoma-forming propensity of secondary neurospheres generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways, which correlated with the persistence of undifferentiated cells.