M
Masawo Kakemi
Researcher at Osaka University of Pharmaceutical Sciences
Publications - 73
Citations - 1617
Masawo Kakemi is an academic researcher from Osaka University of Pharmaceutical Sciences. The author has contributed to research in topics: Intestinal absorption & Gelatin. The author has an hindex of 21, co-authored 73 publications receiving 1514 citations.
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Journal ArticleDOI
Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation
TL;DR: In the hydrogel system, active plasmid DNA was released accompanied with the in vivo degradation of hydrogels, resulting in extended gene expression, controllable by changing the water content ofhydrogels.
Journal ArticleDOI
Application of surface‐coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin
Kazunori Iwanaga,Satoshi Ono,Kohji Narioka,Masawo Kakemi,Kazuhiro Morimoto,Shinji Yamashita,Yukihiro Namba,Naoto Oku +7 more
TL;DR: The ability of surface-coated liposomes, especially of PEG-Lip, to interact with the mucus layer and slow the transit rate in the GI tract is considered desirable for oral delivery of peptide drugs.
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Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract
Kazunori Iwanaga,Satoshi Ono,Kohji Narioka,Kazuhiro Morimoto,Masawo Kakemi,Shinji Yamashita,Mamoru Nango,Naoto Oku +7 more
TL;DR: Results demonstrated that surface coating liposomes with PEG or mucin gained resistance against digestion by bile salts and increased the stability in the GI tract.
Journal ArticleDOI
In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents.
TL;DR: It is concluded that gelatin with a cationization extent of at least 41.6 mol.% is needed for the enhanced in vivo gene expression of plasmid DNA by the hydrogel release system.
Journal ArticleDOI
Characterization of organogel as a novel oral controlled release formulation for lipophilic compounds.
TL;DR: Organogel is clearly useful as an oral controlled release formulation for lipophilic compounds as a gelator for soybean oil and investigated its characteristics as a controlled release formulations for lipophile compounds.