Institution
Hokkaido College of Pharmacy
Education•Sapporo, Japan•
About: Hokkaido College of Pharmacy is a education organization based out in Sapporo, Japan. It is known for research contribution in the topics: Lipid peroxidation & Myocardial stunning. The organization has 281 authors who have published 309 publications receiving 6335 citations.
Papers published on a yearly basis
Papers
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TL;DR: The ability of surface-coated liposomes, especially of PEG-Lip, to interact with the mucus layer and slow the transit rate in the GI tract is considered desirable for oral delivery of peptide drugs.
148 citations
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TL;DR: This work has investigated the oral bioavailability of granules of albendazole, a drug used for treating echinococcosis in man, prepared by the solid dispersion technique.
Abstract: We have investigated the oral bioavailability of granules of albendazole, a drug used for treating echinococcosis in man, prepared by the solid dispersion technique. Rapid dissolution and supersaturation were observed when hydroxypropylmethylcellulose and hydroxypropylmethylcellulose phthalate were used as carriers in the solid dispersion. They inhibited the crystallization of albendazole from the supersaturated solution and maintained an amorphous state for 8 h. Gastric acidity-controlled rabbits were used to evaluate the variation in absorption after oral administration of the albendazole solid dispersion. For rabbits with low gastric acidity the bioavailability of orally administered albendazole in the granular form prepared by solid dispersion was more than three times that of albendazole in physical mixtures. These results suggest that the bioavailability of albendazole in solid dispersions might be high even if there is a great variation in the gastric pH of patients.
135 citations
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TL;DR: Perilla extract suppressed the PCA‐reaction, which was brought about by rosmarinic acid with a partial contribution from some macromolecular compounds, and the anti‐allergic titer of ros marinic acid was more effective than tranilast, which is a modern anti-allergic drug.
Abstract: The leaves of Perilla frutescens Britton (Labiatae) are one of the most popular garnishes in Japan, used as an antidote for fi sh and crab meat allergy or as a food colorant. The present study was conducted to evaluate its anti-allergic effect and to identify its active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction. 48 h after the cutaneous injection of anti-ovalbumin serum into the ears of mice, ovalbumin and evansblue dye were intravenously injected. Perilla was extracted with boiling water, and intraperitoneally injected 15 min before ovalbumin-treatment. Thirty min after ovalbumin-treatment, the ears were removed and the colorant in the ear was colorimetrically quantitated. Perilla extract significantly suppressed the PCA-reaction, which was brought about by rosmarinic acid with a partial contribution from some macromolecular compounds. The anti-allergic titer of rosmarinic acid was more effective than tranilast, which is a modern anti-allergic drug. Perilla and rosmarinic acid are potentially promising agents for the treatment of allergic diseases.
133 citations
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TL;DR: The results suggest that membrane-bound DPP IV loses its transmembrane domain upon release into the serum, and that its structure on the plasma membrane is not required for its binding to adenosine deaminase.
Abstract: Dipeptidyl peptidase IV (DPP IV) in normal human serum was purified 14,400-fold with a 25% yield to homogeneity. The molecular weight of the purified enzyme was approximately 110,000 on SDS-PAGE, almost the same as that of human kidney membrane-bound DPP IV. No difference was found between the two enzymes enzymologically and immunologically, either in substrate specificity, susceptibility to inhibitors, or cross-reactivity with an anti-rat kidney DPP IV antibody, or in their ability to bind adenosine deaminase. However, the N-terminal amino acid sequence of serum DPP IV lacked the transmembrane domain of the membrane-bound enzyme and started at the 39th position, serine, from the N-terminus predicted from the cDNA nucleotide sequence. These results suggest that membrane-bound DPP IV loses its transmembrane domain upon release into the serum, and that its structure on the plasma membrane is not required for its binding to adenosine deaminase.
123 citations
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TL;DR: Metallothionein effectively inhibited the degradation of R-phycoerythrin fluorescence induced by 2,2'-azobis-(2-amidino-propane)-dihydrochloride, suggesting that MT scavenges peroxyl radicals.
109 citations
Authors
Showing all 284 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tetsuya Terasaki | 77 | 399 | 19262 |
Jared J. Grantham | 74 | 206 | 17303 |
Yasuhiko Tabata | 70 | 601 | 18737 |
Satoru Todo | 66 | 400 | 14015 |
Yutaka Kohgo | 57 | 466 | 13289 |
Atsushi Nishida | 35 | 283 | 4320 |
Ken Iseki | 34 | 292 | 5163 |
Shunitz Tanaka | 33 | 174 | 3533 |
Katsumi Miyazaki | 28 | 143 | 2463 |
Hiroshi Suemune | 28 | 152 | 2046 |
Vincent H. Gattone | 27 | 40 | 1802 |
Kazuhiro Morimoto | 27 | 87 | 2427 |
Hiroyuki Akita | 26 | 366 | 3290 |
Toshinobu Seki | 25 | 111 | 2139 |
Shizuko Nagao | 24 | 68 | 2439 |