M
Masaya Nakashima
Publications - 5
Citations - 207
Masaya Nakashima is an academic researcher. The author has contributed to research in topics: DNA damage & Pyrimidine dimer. The author has an hindex of 5, co-authored 5 publications receiving 167 citations.
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Journal ArticleDOI
Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects
Taro Uchiyama,Yusuke Nakano,Osamu Ueda,Hiroshi Mori,Masaya Nakashima,Akira Noda,Chiaki Ishizaki,Masako Mizoguchi +7 more
TL;DR: Examination of the effect of oral intake of pure glucosylceramide derived from konjac extract on skin barrier function evaluated by transepidermal water loss in hairless mice with sodium dodecyl sulfate-induced skin roughness found it to be significantly lower than that in control group.
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Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes.
TL;DR: Overall, the findings indicate that UVB-induced DNA damage initiates NLRP3 inflammasome activation, leading to release of various inflammatory mediators from human keratinocytes, including IL-1β and TNF-α.
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Dietary Glucosylceramide Enhances Cornified Envelope Formation via Transglutaminase Expression and Involucrin Production
TL;DR: Results indicate that the skin barrier improvement induced by oral GlcCer treatment might be at least partly due to a reinforcement of CE formation in the epidermis mediated by sphingoid bases metabolically derived from Glc Cer.
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Chafuroside B, an Oolong tea polyphenol, ameliorates UVB-induced DNA damage and generation of photo-immunosuppression related mediators in human keratinocytes.
TL;DR: Results indicate that chafuroside B promotes repair of UVB-induced DNA damage and ameliorates the generation of IL-10, TNF-α, PGE2, and RANKL, all of which are UVB -induced immunosuppression related mediators.
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Distribution and Metabolism of Sphingosine in Skin after Oral Administration to Mice
TL;DR: Results indicate that SPH is absorbed through the digestive tract and distributed to the skin; second, it is transferred from the dermis to the epidermis; and third, some of the distributed compounds are converted into GlcCer and Cer by biosynthesis.