M
Massimo Bonora
Researcher at University of Ferrara
Publications - 97
Citations - 8969
Massimo Bonora is an academic researcher from University of Ferrara. The author has contributed to research in topics: Mitochondrion & Endoplasmic reticulum. The author has an hindex of 40, co-authored 93 publications receiving 7141 citations. Previous affiliations of Massimo Bonora include Montefiore Medical Center & Albert Einstein College of Medicine.
Papers
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Journal ArticleDOI
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging
Saverio Marchi,Carlotta Giorgi,Jan M. Suski,Jan M. Suski,Chiara Agnoletto,Angela Bononi,Massimo Bonora,Elena De Marchi,Sonia Missiroli,Simone Patergnani,Federica Poletti,Alessandro Rimessi,Jerzy Duszyński,Mariusz R. Wieckowski,Paolo Pinton +14 more
TL;DR: The involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.
Journal ArticleDOI
Ca2+ transfer from the ER to mitochondria: When, how and why
Rosario Rizzuto,Saverio Marchi,Massimo Bonora,Paola Aguiari,Angela Bononi,Diego De Stefani,Carlotta Giorgi,Carlotta Giorgi,Sara Leo,Alessandro Rimessi,Roberta Siviero,Roberta Siviero,Erika Zecchini,Erika Zecchini,Paolo Pinton +14 more
TL;DR: This review will summarize the current knowledge of the mitochondrial and ER Ca(2+) channels mediating the ion transfer, the structural and molecular foundations of the signaling contacts between the two organelles, and the functional consequences of the [Ca(2+)]m increases.
Journal ArticleDOI
Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition
Massimo Bonora,Angela Bononi,Elena De Marchi,Carlotta Giorgi,Magdalena Lebiedzinska,Saverio Marchi,Simone Patergnani,Alessandro Rimessi,Jan M. Suski,Aleksandra Wojtala,Mariusz R. Wieckowski,Guido Kroemer,Lorenzo Galluzzi,Paolo Pinton +13 more
TL;DR: It is demonstrated that the c subunit of the FO ATP synthase is required for MPT, mitochondrial fragmentation and cell death as induced by cytosolic calcium overload and oxidative stress in both glycolytic and respiratory cell models.
Journal ArticleDOI
PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release
Carlotta Giorgi,Keisuke Ito,Keisuke Ito,Hui Kuan Lin,Clara Santangelo,Mariusz R. Wieckowski,Magdalena Lebiedzinska,Angela Bononi,Massimo Bonora,Jerzy Duszyński,Rosa Bernardi,Rosa Bernardi,Rosario Rizzuto,Carlo Tacchetti,Paolo Pinton,Paolo Pinton,Paolo Pinton,Pier Paolo Pandolfi,Pier Paolo Pandolfi +18 more
TL;DR: It is shown that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca2+) transport and in induction of apoptosis.
Book ChapterDOI
Relation between mitochondrial membrane potential and ROS formation.
Jan M. Suski,Magdalena Lebiedzinska,Massimo Bonora,Paolo Pinton,Jerzy Duszynski,Mariusz R. Wieckowski +5 more
TL;DR: A relation between mitochondrial membrane potential and the rate of ROS formation is described and experiments demonstrating that a magnitude and a direction of a change in mitochondrial ROS production depends on the metabolic state of this organelle are presented.