M
Mathew C. Casimiro
Researcher at Thomas Jefferson University
Publications - 72
Citations - 6038
Mathew C. Casimiro is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cyclin D1 & Cyclin D. The author has an hindex of 38, co-authored 69 publications receiving 5447 citations. Previous affiliations of Mathew C. Casimiro include Georgetown University & Georgetown University Medical Center.
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides,Diana Whitaker-Menezes,Remedios Castello-Cros,Neal Flomenberg,Agnieszka K. Witkiewicz,Philippe G. Frank,Mathew C. Casimiro,Chenguang Wang,Paolo Fortina,Sankar Addya,Richard G. Pestell,Ubaldo E. Martinez-Outschoorn,Federica Sotgia,Michael P. Lisanti +13 more
TL;DR: In this alternative model of tumorigenesis, the epithelial cancer cells instruct the normal stroma to transform into a wound-healing stroma, providing the necessary energy-rich micro-environment for facilitating tumor growth and angiogenesis, explaining its powerful predictive value.
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A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Zuoren Yu,Chenguang Wang,Min Wang,Zhiping Li,Mathew C. Casimiro,Manran Liu,Kongming Wu,James R. Whittle,Xiaoming Ju,Terry Hyslop,Peter McCue,Richard G. Pestell +11 more
TL;DR: These studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclinD1 induces miR- 17-5p/mi R-20a and limits the proliferative function of cyclIn D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis.
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The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
Stephanos Pavlides,Aristotelis Tsirigos,Gemma Migneco,Diana Whitaker-Menezes,Barbara Chiavarina,Neal Flomenberg,Philippe G. Frank,Mathew C. Casimiro,Chenguang Wang,Richard G. Pestell,Ubaldo E. Martinez-Outschoorn,Anthony Howell,Federica Sotgia,Michael P. Lisanti +13 more
TL;DR: Transcriptional profiling of Cav-1 (-/-) stromal cells and human tumor stroma from breast cancer patients directly supported an association with oxidative stress, mitochondrial dysfunction, and autophagy/mitophagy, as well as ADMA and ketone production.
Journal ArticleDOI
Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome
Mathew C. Casimiro,Bjorn C. Knollmann,Steven N. Ebert,Jay C. Vary,Anne E. Greene,Michael R. Franz,Alexander Grinberg,Sing Ping Huang,Karl Pfeifer +8 more
TL;DR: In this paper, a line of transgenic mice that have a targeted disruption in the Kcnq1 gene was generated to generate a mouse model for JLNS, and behavioral analysis revealed that the mice are deaf and exhibit a shaker/waltzer phenotype.
Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange
Mathew C. Casimiro,Steven N. Ebert,Jay C. Vary,Anne E. Greene,Michael R. Franz,Alexander Grinberg,Sing Ping Huang,Karl Pfeifer +7 more
TL;DR: Data suggest that Kcnq1−/− mice are a potentially valuable animal model of JLNS, a disorder characterized by profound bilateral deafness and a cardiac phenotype caused by loss-of-function mutations in the human KCNQ1 gene.