Z
Zuoren Yu
Researcher at Tongji University
Publications - 77
Citations - 3230
Zuoren Yu is an academic researcher from Tongji University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 25, co-authored 64 publications receiving 2507 citations. Previous affiliations of Zuoren Yu include Wenzhou Medical College & Thomas Jefferson University.
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Journal ArticleDOI
Cancer Stem Cells
TL;DR: The current understanding of cancer stem cells is summarized, with a focus on the role of miRNA and epithelial-mesenchymal transition (EMT), and the clinical application of targeting CSCs for cancer treatment is discussed.
Journal ArticleDOI
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Zuoren Yu,Chenguang Wang,Min Wang,Zhiping Li,Mathew C. Casimiro,Manran Liu,Kongming Wu,James R. Whittle,Xiaoming Ju,Terry Hyslop,Peter McCue,Richard G. Pestell +11 more
TL;DR: These studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclinD1 induces miR- 17-5p/mi R-20a and limits the proliferative function of cyclIn D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis.
Journal ArticleDOI
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling
Zuoren Yu,Nicole E. Willmarth,Jie Zhou,Sanjay Katiyar,Min Wang,Yang Liu,Peter McCue,Andrew A. Quong,Michael P. Lisanti,Richard G. Pestell +9 more
TL;DR: These findings not only reveal an antiinvasive function of miR-17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA regulation of tumor metastasis.
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p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
Manran Liu,Mathew C. Casimiro,Chenguang Wang,L. Andrew Shirley,Xuanmao Jiao,Sanjay Katiyar,Xiaoming Ju,Zhiping Li,Zuoren Yu,Jie Zhou,Michael D. Johnson,Paolo Fortina,Terry Hyslop,Jolene J. Windle,Richard G. Pestell +14 more
TL;DR: A link between the loss of p21CIP1 and the acquisition of breast cancer EMT and stem cell properties in vivo is established.
Journal ArticleDOI
Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression
Maria Genander,Michael M. Halford,Nan-Jie Xu,Malin Eriksson,Zuoren Yu,Zhaozhu Qiu,Anna Martling,Gedas Greicius,Sonal Thakar,Timothy Catchpole,Michael J. Chumley,Sofia Zdunek,Chenguang Wang,Torbjörn Holm,Stephen P. Goff,Sven Pettersson,Richard G. Pestell,Mark Henkemeyer,Jonas Frisén +18 more
TL;DR: The dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth.