M
Mathias Winterhalter
Researcher at Jacobs University Bremen
Publications - 262
Citations - 12392
Mathias Winterhalter is an academic researcher from Jacobs University Bremen. The author has contributed to research in topics: Membrane & Bacterial outer membrane. The author has an hindex of 57, co-authored 250 publications receiving 10692 citations. Previous affiliations of Mathias Winterhalter include Paul Sabatier University & International University, Cambodia.
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The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
TL;DR: The bacterial response towards antibiotic stress on altered membrane permeability is outlined and recent advances in molecular approaches that are improving knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels are discussed.
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Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores
TL;DR: It is hypothesized that, in analogy to substrate-specific channels that evolved to bind certain metabolite molecules, antibiotics have “evolved” to be channel-specific.
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Nanoreactors based on (polymerized) ABA-triblock copolymer vesicles
TL;DR: A new kind of nanoreactor has been prepared by the incorporation of a channel protein into the shell of polymerized vesicles formed from an amphiphilic ABA-triblock copolymer.
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Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer.
TL;DR: By increasing the lipid concentration, increasing the number of freeze-thaw cycles and enhancing the interactions of the enzyme with the liposome lipid surface more than 40% of the initial total activity can be encapsulated.
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Nanoengineered polymer capsules: tools for detection, controlled delivery, and site-specific manipulation.
Gleb B. Sukhorukov,Andrey L. Rogach,Bernd Zebli,Tim Liedl,Andre G. Skirtach,Karen Köhler,Alexei Antipov,Nikolai Gaponik,Andrei S. Susha,Mathias Winterhalter,Wolfgang J. Parak +10 more
TL;DR: The concept of multifunctional nanoengineered polymer capsules is presented and their applications as new drug delivery systems or supramolecular toolboxes containing, for example, enzymes capable of converting nontoxic prodrugs into toxic drugs at a designated location are outlined.