M
Mathilde H. Lerche
Researcher at Technical University of Denmark
Publications - 85
Citations - 7124
Mathilde H. Lerche is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Hyperpolarization (physics) & Nuclear magnetic resonance spectroscopy. The author has an hindex of 28, co-authored 83 publications receiving 6526 citations. Previous affiliations of Mathilde H. Lerche include University of Copenhagen & GE Healthcare.
Papers
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Journal ArticleDOI
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
Jan Henrik Ardenkjær-Larsen,Björn Fridlund,Andreas Gram,Georg Hansson,Lennart Hansson,Mathilde H. Lerche,Rolf Servin,Mikkel Thaning,Klaes Golman +8 more
TL;DR: The method can be used generally for signal enhancement and reduction of measurement time in liquid-state NMR and opens up for a variety of in vitro and in vivo applications of DNP-enhanced NMR.
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Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.
Sam E. Day,Mikko I. Kettunen,Ferdia A. Gallagher,De-En Hu,Mathilde H. Lerche,Jan Wolber,Klaes Golman,Jan Henrik Ardenkjær-Larsen,Kevin M. Brindle +8 more
TL;DR: In lymphoma-bearing mice injected intravenously with hyperpolarized [1-13C]pyruvate, it is shown that the lactate dehydrogenase–catalyzed flux of 13C label between the carboxyl groups of pyruvates and lactate in the tumor can be measured using 13C magnetic resonance spectroscopy and spectroscopic imaging, and that this flux is inhibited within 24 h of chemotherapy.
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Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
Ferdia A. Gallagher,Mikko I. Kettunen,Sam E. Day,De-En Hu,Jan Henrik Ardenkjær-Larsen,René in ‘t Zandt,Pernille Rose Jensen,Magnus Karlsson,Klaes Golman,Mathilde H. Lerche,Kevin M. Brindle +10 more
TL;DR: Tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate and 13CO2 following intravenous injection of hyperPolarized H13CO3-.
Journal ArticleDOI
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.
TL;DR: The results indicate that noninvasive quantification of localized Warburg effect may be possible for cancer diagnosis and treatment in animals and humans.
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Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors
Ferdia A. Gallagher,Mikko I. Kettunen,De-En Hu,Pernille Rose Jensen,René in ‘t Zandt,Magnus Karlsson,Anna Gisselsson,Sarah K. Nelson,Timothy H. Witney,Sarah E. Bohndiek,Georg Hansson,Torben Peitersen,Mathilde H. Lerche,Kevin M. Brindle +13 more
TL;DR: The formation of hyperpolarized 13C-labeled malate from [1,4-13C2]fumarate appears to be a sensitive marker of tumor cell death in vivo and could be used to detect the early response of tumors to treatment.