Matteo Marconi

TL;DR: The results underscore the relevance of the modulation of autophagy in the GSC survival and death and suggest that triggering of ferroptosis in GSCs could represent a novel and important target for the management of glioblastoma.

TL;DR: It is shown that adipocyte MR regulates brown remodeling of WAT through a modulation of autophagy, which provides a rationale for the use of MR antagonists to prevent the adverse metabolic consequences of adipocyte dysfunction in high‐fat‐diet‐fed mice.

TL;DR: It is hypothesized that MAM raft-like microdomains could be pivotal in the initial organelle scrambling activity that finally leads to the formation of autophagosome.

TL;DR: Results suggest that gangliosides, via their molecular interaction with autophagy-associated molecules, could be recruited to autophagosome and contribute to morphogenic remodeling, e.g., to changes of membrane curvature and fluidity, finally leading to mature autolysosome formation.

TL;DR: Results provide a key mechanism for TRAIL sensitivity in B-cell malignances: the association, within lipid microdomains, of DR4 but not DR5, with a specific ganglioside, that is the monosialogangliosides GM3.