L
Luigi Maria Larocca
Researcher at Catholic University of the Sacred Heart
Publications - 394
Citations - 14607
Luigi Maria Larocca is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Cancer & Lymphoma. The author has an hindex of 60, co-authored 372 publications receiving 13128 citations. Previous affiliations of Luigi Maria Larocca include University of Bologna & The Catholic University of America.
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Journal ArticleDOI
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Parati,Giorgio Stassi,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: A variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin.
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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Giulia Fabbri,Silvia Rasi,Davide Rossi,Vladimir Trifonov,Hossein Khiabanian,Jing Ma,Adina Grunn,Marco Fangazio,Daniela Capello,Sara Monti,Stefania Cresta,Ernesto Gargiulo,Francesco Forconi,Anna Guarini,Luca Arcaini,Marco Paulli,Luca Laurenti,Luigi Maria Larocca,Roberto Marasca,Valter Gattei,David Oscier,Francesco Bertoni,Charles G. Mullighan,Robin Foà,Laura Pasqualucci,Raul Rabadan,Riccardo Dalla-Favera,Gianluca Gaidano +27 more
TL;DR: Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
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Chemotherapy resistance of glioblastoma stem cells
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Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme
Roberto Pallini,Lucia Ricci-Vitiani,Giuseppe Luigi Banna,Michele Signore,Dario Giuseppe Lombardi,Matilde Todaro,Giorgio Stassi,Maurizio Martini,Giulio Maira,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: The analysis of CSCs may predict the survival of glioblastoma patients and in vitro CSC generation and presence of CD133+/Ki67+ cells are two considerable prognostic factors of disease progression and poor clinical outcome.
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The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
Davide Rossi,Valeria Spina,Clara Deambrogi,Silvia Rasi,Luca Laurenti,Kostas Stamatopoulos,Luca Arcaini,Marco Lucioni,Gabrielle B. Rocque,Zijun Y. Xu-Monette,Carlo Visco,Julie Chang,Ekaterina Chigrinova,Francesco Forconi,Roberto Marasca,Caroline Besson,Theodora Papadaki,Marco Paulli,Luigi Maria Larocca,Stefano Pileri,Valter Gattei,Francesco Bertoni,Robin Foà,Ken H. Young,Gianluca Gaidano +24 more
TL;DR: The molecular dissection of RS into biologically distinct categories highlights the genetic heterogeneity of this disorder and provides clinically relevant information for refining the prognostic stratification of patients.