Matteo Nobili

TL;DR: A phenomenological model for platelet cumulative damage, identified by means of genetic algorithms (GAs) was correlated with in vitro experiments conducted in a Hemodynamic Shearing Device (HSD), and model predictions were in very good agreement with the experimental results.

TL;DR: The favorable agreement obtained between in vitro and in silico results of the leaflet displacements confirms the consistency of the numerical method used, and candidates the application of FSI models to become a major tool to optimize the MHV design and eventually provides useful information to surgeons.

TL;DR: An integrated Lagrangian description of key flow characteristics could provide a more complete and quantitative picture of blood flow through MHVs and its potential to activate platelets: the proposed "comprehensive scale" approach could represent an efficient and novel assessment tool for MHV performance and may possibly lead to improved valve designs.

TL;DR: 3D numerical simulation of the opening transient for a bileaflet mechanical heart valve and the strong coupling model provides a more consistent physical description of the interaction when looking at small-scale features like stress close to geometrical singularities.

TL;DR: A phenomenological model for platelet cumulative damage was developed and the proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.