M
Matthew D. Daugherty
Researcher at University of California, San Diego
Publications - 48
Citations - 3888
Matthew D. Daugherty is an academic researcher from University of California, San Diego. The author has contributed to research in topics: RNA & Medicine. The author has an hindex of 23, co-authored 38 publications receiving 3317 citations. Previous affiliations of Matthew D. Daugherty include Fred Hutchinson Cancer Research Center & University of California, Berkeley.
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Journal ArticleDOI
Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655
Svetlana Gerdes,Michael D. Scholle,James W. Campbell,Gábor Balázsi,Erzsébet Ravasz,Matthew D. Daugherty,A. L. Somera,Nikos C. Kyrpides,Iain Anderson,Mikhail S. Gelfand,A. Bhattacharya,Vinayak Kapatral,Mark D'Souza,Mark V. Baev,Yuri Grechkin,Faika Mseeh,Michael Fonstein,Ross Overbeek,Albert-László Barabási,Zoltán N. Oltvai,Andrei L. Osterman +20 more
TL;DR: A genetic footprinting technique is used for a genome-wide assessment of genes required for robust aerobic growth of Escherichia coli in rich media to identify 620 genes as essential and 3,126 genes as dispensable for growth under these conditions.
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Rules of Engagement: Molecular Insights from Host-Virus Arms Races
TL;DR: Common rules for the strategies employed by both hosts and viruses have emerged from case studies of innate immunity genes in primates and are poised to be used to transition from a retrospective view of host-virus arms races to specific predictions about which host genes face pathogen antagonism and how those genetic conflicts transform host and virus evolution.
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From Genetic Footprinting to Antimicrobial Drug Targets: Examples in Cofactor Biosynthetic Pathways
Svetlana Gerdes,Michael D. Scholle,Mark D'Souza,Axel Bernal,Mark V. Baev,Michael A. Farrell,Oleg V. Kurnasov,Matthew D. Daugherty,Faika Mseeh,Boris Polanuyer,John W. Campbell,Shubha Anantha,Konstantin Shatalin,Shamim A. K. Chowdhury,Michael Fonstein,Andrei L. Osterman +15 more
TL;DR: An integrated approach to identification and prioritization of broad-spectrum drug targets is described, based on genetic footprinting in Escherichia coli followed by metabolic context analysis of essential gene orthologs in various species.
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Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.
Matthew D. Daugherty,Boris Polanuyer,Michael L. Farrell,Michael D. Scholle,Athanasios Lykidis,Valérie de Crécy-Lagard,Andrei L. Osterman +6 more
TL;DR: Using comparative genomics, human genes encoding the last four enzymatic steps in CoA biosynthesis are identified and human recombinant bifunctional phosphopantetheine adenylyltransferase/dephospho-CoA kinase was kinetically characterized.
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Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.
TL;DR: It is shown that ligand binding is required for the subsequent co-oligomerization of NAIPs with the downstream signaling adaptor NLR family, CARD-containing 4 (NLRC4), and Interestingly, the ligand specificity domain has evolved under positive selection in both rodents and primates.