Matthew J. Dalby

TL;DR: The introduction of a bioactive phase, such as hydroxyapatite (HA), to cement may enhance fixation by encouraging direct bone apposition rather than encapsulation of the implant by fibrous tissue.

TL;DR: The data demonstrate that osteogenic nanotopography promotes colocalization of integrins and BMP2 receptors in order to enhance osteogenic activity and that vitronectin is important in this interface provides insight that topographical regulation of adhesion can have effects on signaling cascades outside of cytoskeletal signaling and that adhesions can have roles in augmenting BMP signaling.

TL;DR: It is concluded from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.

TL;DR: This review will investigate the range of nanotopographies available to researchers and the present understanding of mechanisms of progenitor cell response, and make some speculations of the future of nanomaterials and progenitors cells in tissue engineering.

TL;DR: A nanotopographical systems approach linked to metabolomics is applied to regulate plasticity and demonstrate rapid metabolite reorganization, allowing rational selection of key biochemical targets of self-renewal and it is shown that these signaling effectors regulate functional multipotency.