P. Monica Tsimbouri

TL;DR: The study identifies a nanostructured surface that retains stem-cell phenotype and maintains stem- cell growth over eight weeks, and implicates a role for small RNAs in repressing key cell signalling and metabolomic pathways, demonstrating the potential of surfaces as non-invasive tools with which to address the stem cell niche.

TL;DR: A nanotopographical systems approach linked to metabolomics is applied to regulate plasticity and demonstrate rapid metabolite reorganization, allowing rational selection of key biochemical targets of self-renewal and it is shown that these signaling effectors regulate functional multipotency.

TL;DR: A first demonstration of using nanoscale sinusoidal mechanotransductive protocols, "nanokicking", to promote osteoblastogenesis in human mesenchymal stem cell cultures, using the reverse piezo effect to develop the optimal stem cell stimulation conditions.

TL;DR: The main focus of this review is the use of biomaterials as a tool for examining mechanotrandsuctive effects on self‐renewal and differentiation in stem cells.

TL;DR: The ability to induce osteoblatogenesis in MSCs using high-frequency piezo-driven nanodisplacements in a vertical direction provides confidence in nanomechanotransduction for stem cell differentiation without dependence on soluble factors and complex chemistries.