M
Matthew L. Mayer
Researcher at University of British Columbia
Publications - 13
Citations - 1042
Matthew L. Mayer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 11, co-authored 13 publications receiving 936 citations.
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Journal ArticleDOI
Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment
Anastasia Nijnik,Laurence Madera,Shuhua Ma,Matthew Waldbrook,Melissa Elliott,Donna M. Easton,Matthew L. Mayer,Sarah C. Mullaly,Jason Kindrachuk,Haûvard Jenssen,Robert E. W. Hancock +10 more
TL;DR: It is demonstrated that the optimization of the ex vivo chemokine-induction properties of peptides is a promising method for the rational development of immunomodulatory IDR peptides with enhanced anti-infective activity.
Journal ArticleDOI
Potential of immunomodulatory host defense peptides as novel anti-infectives
TL;DR: The potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway are discussed.
Journal ArticleDOI
INMEX—a web-based tool for integrative meta-analysis of expression data
Jianguo Xia,Christopher D. Fjell,Matthew L. Mayer,Olga M. Pena,David S. Wishart,Robert E. W. Hancock +5 more
TL;DR: Integrative meta-analysis of expression data (INMEX) is introduced, a user-friendly web-based tool designed to support meta- analysis of multiple gene-expression data sets, as well as to enable integration of data sets from gene expression and metabolomics experiments.
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Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria
Ariel H. Achtman,Ariel H. Achtman,Sandra Pilat,Sandra Pilat,Charity W. Law,Charity W. Law,David J. Lynn,David J. Lynn,David J. Lynn,Laure Janot,Matthew L. Mayer,Shuhua Ma,Jason Kindrachuk,B. Brett Finlay,Fiona S. L. Brinkman,Gordon K. Smyth,Gordon K. Smyth,Robert E. W. Hancock,Louis Schofield,Louis Schofield +19 more
TL;DR: The authors adapted the murine Plasmodium berghei ANKA ECM model to serve as a preclinical drug-screening platform by combining antimalarial drug intervention in established malarial infections with iterative mouse-human bioinformatic analysis of early transcriptional changes in co-regulated gene sets.
Journal ArticleDOI
Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells
Matthew L. Mayer,Christoph J. Blohmke,Reza Falsafi,Chris Fjell,Laurence Madera,Stuart E. Turvey,Robert E. W. Hancock +6 more
TL;DR: It is suggested that dysfunctional autophagosome clearance contributes to heightened inflammatory responses from CF transmembrane receptor mutant cells and autophagy and AMPK–Akt signaling are highlighted as novel anti-inflammatory targets in CF.