M
Matthew McConnell
Researcher at Yale University
Publications - 17
Citations - 295
Matthew McConnell is an academic researcher from Yale University. The author has contributed to research in topics: Liver injury & Cirrhosis. The author has an hindex of 4, co-authored 14 publications receiving 78 citations.
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Journal ArticleDOI
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Tingting Su,Yilin Yang,Sanchuan Lai,Jain Jeong,Yirang Jung,Matthew McConnell,Teruo Utsumi,Yasuko Iwakiri +7 more
TL;DR: This study mapped the spatial distribution of heterogeneous liver ECs in normal vs cirrhotic mouse livers and identified zone-specific transcriptomic changes of LSECs associated with liver cirrhosis using scRNA-seq technology, which deepens knowledge of the pathogenesis of liver Cirrhosis at a spatial, cell-specific level.
Journal ArticleDOI
Biology of portal hypertension
Matthew McConnell,Yasuko Iwakiri +1 more
TL;DR: The role of microvascular thrombosis and platelet function in the pathogenesis of portal hypertension remains to be clearly characterized as discussed by the authors, and the role of the mesenteric vasculature in portal hypertension has been extensively studied.
Journal ArticleDOI
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.
Matthew McConnell,Nao Kawaguchi,Reiichiro Kondo,Reiichiro Kondo,Aurelio Sonzogni,Lisa Licini,Clarissa Valle,Pietro Andrea Bonaffini,Sandro Sironi,Maria Alessio,Giulia Previtali,Michela Seghezzi,Xuchen Zhang,Alfred Ian Lee,Alexander B Pine,Hyung J. Chun,Xinbo Zhang,Carlos Fernández-Hernando,Hua Qing,Andrew Wang,Christina Price,Zhaoli Sun,Teruo Utsumi,John Hwa,Mario Strazzabosco,Yasuko Iwakiri +25 more
TL;DR: In this paper, the IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state) and liver injury in COVID-19.
Journal ArticleDOI
Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats.
Shao-Jung Hsu,Shao-Jung Hsu,Chihao Zhang,Jain Jeong,Seong-il Lee,Matthew McConnell,Teruo Utsumi,Yasuko Iwakiri +7 more
TL;DR: Manipulation of meningeal lymphangiogenesis could be a new therapeutic strategy for the treatment of Hepatic encephalopathy and enhance waste clearance improves HE.
Covid-19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis.
TL;DR: In this article, vascular inflammation and thrombosis were presented as a potential mechanism of liver injury and liver-related complications in coronavirus disease 2019 (COVID-19) symptoms caused by SARS-CoV-2.