M
Matthew Me Hurles
Researcher at Wellcome Trust Sanger Institute
Publications - 1
Citations - 234
Matthew Me Hurles is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Somatic cell & Germline mutation. The author has an hindex of 1, co-authored 1 publications receiving 185 citations.
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Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Young Seok Ju,Young Seok Ju,Inigo Martincorena,Moritz Gerstung,Moritz Gerstung,Mia Petljak,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Raheleh Rahbari,David C. Wedge,Helen Davies,Manasa Ramakrishna,Anthony Fullam,Sancha Martin,Christopher Alder,Nikita Patel,Steve Gamble,Sarah O’Meara,Dilip Giri,Torril Sauer,S. Pinder,Colin A. Purdie,Åke Borg,Henk Stunnenberg,Marc J. van de Vijver,Benita Kiat Tee Bk Tan,Carlos Caldas,Andrew Tutt,Andrew Tutt,Naoto T. Ueno,Laura Van't Veer,John W.M. Martens,Christos Sotiriou,Stian Knappskog,Paul N. Span,Sunil R. Lakhani,Jorunn E. Eyfjord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Alastair M Thompson,Alain Viari,Matthew Me Hurles,Serena Nik-Zainal,Peter J. Campbell,Michael R. Stratton +45 more
TL;DR: Insight is provided into the mutation rates, mutational processes and developmental outcomes of cell dynamics that operate during early human embryogenesis and it is demonstrated that the two daughter cells of many early embryonic cell-doubling events contribute asymmetrically to adult blood at an approximately 2:1 ratio.