M
Matthew P. Scott
Researcher at Stanford University
Publications - 242
Citations - 39913
Matthew P. Scott is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Hedgehog. The author has an hindex of 98, co-authored 233 publications receiving 38468 citations. Previous affiliations of Matthew P. Scott include National Institutes of Health & Carnegie Institution for Science.
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Journal ArticleDOI
Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain
Nobutaka Ohgami,Dennis C. Ko,Matthew B. Thomas,Matthew P. Scott,Catherine C.Y. Chang,Ta-Yuan Chang +5 more
TL;DR: There is direct binding between NPC1 and azocholestanol; the binding does not require NPC2 but requires a functional SSD within NPC1, and cholesterol is more effective in protection against labeling than its analogs epicholesterol or 5-alpha-cholestan.
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The integrity of a cholesterol-binding pocket in Niemann–Pick C2 protein is necessary to control lysosome cholesterol levels
TL;DR: This paper found that purified NPC2, a secreted soluble protein, binds cholesterol specifically with a much higher affinity (Kd = 30-50 nM) than previously reported, and identified single amino acid changes that prevent both cholesterol binding and the restoration of normal cholesterol levels in mutant cells.
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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
TL;DR: Using Drosophila salivary gland cells in vivo and in vitro as a new assay for Hh signal transduction, the regulation of Hh-triggered Smo stabilization and relocalization is investigated.
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Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C Disease
Dennis C. Ko,Ljiljana Milenkovic,Steven M Beier,Hermogenes Manuel,JoAnn Buchanan,Matthew P. Scott +5 more
TL;DR: Chimeric mice exhibited a remarkable delay and reduction of wasting and ataxia despite their substantial amount of mutant tissue and dying cells, revealing a robust mechanism that partially compensates for massive PC death.
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Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.
TL;DR: Data from recent studies are assimilated to understand how and when the Hh pathway is turned on to aid the neoplastic process, enabling categorization of tumors based on the role Hh signaling plays in their growth.