Matthew S. P. Boyles

TL;DR: Chitosan functionalization of NPs, with resultant high surface charges plays an important role in NP-toxic effects and is dependent on the core material of the particle, the cell type used for testing and the growth characteristics of these cell culture model systems.

TL;DR: This study demonstrates that CNTs are potentially pathogenic, as they were routinely found to induce detrimental responses in macrophages greater than those induced by asbestos at the same mass-based dose.

TL;DR: Strong cytotoxic and genotoxic effects were observed in cells exposed to Ag ENMs 50 nm, but Ag ENM 200 nm had the most mutagenic potential, and it was found that the toxicity of Ag ENm is not always size dependent.

TL;DR: It can be concluded that functionalisation of AuNPs with the perceived non-toxic biocompatible molecule chitosan at a high density can elicit functionalisation-dependent intracellular trafficking mechanisms and provoke strong pro-inflammatory conditions, and that a high affinity of these NP-conjugates for biomolecules may be implicit in these cellular responses.

TL;DR: Investigation of the ability of a series of different surface-coated quantum dots (QDs) to cause oxidative stress and affect cell signalling in J774.A1 macrophages concluded that QDs differ in their interactions with macrophage according to their specific surface properties.