M
Matthews Chacko
Researcher at Cleveland Clinic
Publications - 6
Citations - 652
Matthews Chacko is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Myocardial infarction & Percutaneous coronary intervention. The author has an hindex of 4, co-authored 6 publications receiving 628 citations.
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Journal ArticleDOI
SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction
Ming Zhang,Niladri Mal,Matthew Kiedrowski,Matthews Chacko,Arman T. Askari,Zoran B. Popović,Omer N. Koc,Marc S. Penn +7 more
TL;DR: The results indicate that stem cell transplantation may have significant beneficial effects on injured organ function independent of tissue regeneration and identify SDF‐1:CXCR4 binding as a novel target for myocardial preservation.
Journal ArticleDOI
Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial
Stephen G. Ellis,Marc S. Penn,Brian J. Bolwell,Mario J. Garcia,Matthews Chacko,Thomas H. Wang,Kelly J. Brezina,Gerry McConnell,Eric J. Topol +8 more
TL;DR: Despite demonstrated mobilization of precursor stem cells in a timely fashion, in this small, pilot-scale randomized trial involving patients with large myocardial infarction, it was unable to demonstrate improvement in left ventricular function at 30 days.
Journal ArticleDOI
Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl)
John W. McEvoy,Khalil Ibrahim,Thomas S. Kickler,William Clarke,Rani K. Hasan,Matthew J. Czarny,Ali R. Keramati,Rakesh R. Goli,Travis P. Gratton,Jeffrey A. Brinker,Matthews Chacko,Chao Wei Hwang,Peter V. Johnston,Julie M. Miller,Jeffrey C. Trost,William R. Herzog,Roger S. Blumenthal,David R. Thiemann,Jon R. Resar,Steven P. Schulman +19 more
TL;DR: A single-center PACIFY trial randomized adults undergoing clinically indicated elective coronary angiography to receive the procedure with or without intravenous fentanyl, a potent opiate commonly administered during cardiac catheterization procedures in North America.
Journal ArticleDOI
Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)–2 trial
Matthews Chacko,A. Michael Lincoff,Katherine E. Wolski,David J. Cohen,John A. Bittl,Alexandra J. Lansky,Yoshihiro Tsuchiya,Amadeo Betriu,Michael H. Yen,Derek P. Chew,Leslie Cho,Eric J. Topol +11 more
TL;DR: Bivalirudin with provisional GpIIb-IIIa confers similar protection against ischemic end points compared with heparin and planned Gp IIb- IIIa blockade and significantly reduces the inherent bleeding risk of women undergoing contemporary PCI.
Journal Article
Asymptomatic acute inferior ST elevation myocardial infarction from thermal injury complicating radiofrequency ablation for atrioventricular re-entrant tachycardia.
TL;DR: An unusual mechanism leading to acute myocardial infarction as a complication of a commonly performed electrophysiology procedure that should be recognized by both interventionalists and electrophYSiologists and treated aggressively with percutaneous revascularization is presented.