M
Matthias Dobbelstein
Researcher at University of Göttingen
Publications - 131
Citations - 7867
Matthias Dobbelstein is an academic researcher from University of Göttingen. The author has contributed to research in topics: Gene & Viral replication. The author has an hindex of 43, co-authored 123 publications receiving 7118 citations. Previous affiliations of Matthias Dobbelstein include Princeton University & University of Southern Denmark.
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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
TL;DR: It is shown here that the hdm2 oncoprotein constantly shuttles between the nucleus and the cytoplasm, and the rev nuclear export pathway may be used to regulate an oncogene product's activity and modulate cellular growth.
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p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
Christian Braun,Xin Zhang,Irina Savelyeva,Sonja Wolff,Ute M. Moll,Troels Schepeler,Torben F. Ørntoft,Claus L. Andersen,Matthias Dobbelstein +8 more
TL;DR: Here, array hybridization is used to find that p53 induces two additional, mutually related clusters of microRNAs, leading to the up-regulation of miR-192,MiR-194, and miR -215, which seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest.
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Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
Evguenia M. Alexandrova,Alisha R. Yallowitz,Dun Li,S Xu,Ramona Schulz,D. A. Proia,Guillermina Lozano,Matthias Dobbelstein,Ute M. Moll +8 more
TL;DR: It is shown that long-term HSP90 inhibition significantly extends the survival of mutp53 Q/− (R248Q allele) and H/H (R172H allele) mice by 59% and 48%, respectively, but not their corresponding p53−/− littermates, and drug activity correlates with induction ofmutp53 degradation, tumour apoptosis and prevention of T-cell lymphomagenesis.
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Nucleo-cytoplasmic shuttling of the HDM2 oncoprotein regulates the levels of P53 protein VIA a pathway USED by the human immunodeficiency virus REV protein
TL;DR: It is shown here that the hdm2 oncoprotein constantly shuttles between the nucleus and the cytoplasm, and the rev nuclear export pathway may be used to regulate an oncogene product's activity and modulate cellular growth.
Journal ArticleDOI
A polymorphic microsatellite that mediates induction of PIG3 by p53.
TL;DR: It is shown that p53 directly binds and activates the PIG3 promoter, but not through the previously described DNA element, which is the first time that a microsatellite has been shown to mediate the induction of a promoter through direct interaction with a transcription factor.