C
Claus L. Andersen
Researcher at Aarhus University Hospital
Publications - 148
Citations - 18604
Claus L. Andersen is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 50, co-authored 124 publications receiving 15491 citations. Previous affiliations of Claus L. Andersen include The Royal Marsden NHS Foundation Trust & National Institutes of Health.
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Journal ArticleDOI
Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets
TL;DR: A novel, innovative, and robust strategy to identify stably expressed genes among a set of candidate normalization genes, rooted in a mathematical model of gene expression, that provides a direct measure for the estimated expression variation, enabling the user to evaluate the systematic error introduced when using the gene.
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova,Nousin Rezaei,Michalis Liontos,Panagiotis Karakaidos,Dimitris Kletsas,Natalia Issaeva,Leandros-Vassilios F. Vassiliou,Evangelos Kolettas,Katerina Niforou,Vassilis Zoumpourlis,Munenori Takaoka,Hiroshi Nakagawa,Frederic Tort,Kasper Fugger,Fredrik Johansson,Maxwell Sehested,Claus L. Andersen,Lars Dyrskjøt,Torben F. Ørntoft,Jiri Lukas,Christos Kittas,Thomas Helleday,Thomas Helleday,Thanos D. Halazonetis,Thanos D. Halazonetis,Jiri Bartek,Vassilis G. Gorgoulis +26 more
TL;DR: It is shown that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks, and, together with apoptosis, provides a barrier to malignant progression.
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Direct detection of early-stage cancers using circulating tumor DNA
Jillian Phallen,Mark Sausen,Vilmos Adleff,Alessandro Leal,Carolyn Hruban,James R. White,Valsamo Anagnostou,Jacob Fiksel,Stephen Cristiano,Eniko Papp,Savannah Speir,Thomas Reinert,Mai-Britt Worm Ørntoft,Brian Woodward,Derek Murphy,Sonya Parpart-Li,David R. Riley,Monica Nesselbush,Naomi Sengamalay,Andrew Georgiadis,Qing Kay Li,Mogens Madsen,Frank Viborg Mortensen,Joost Huiskens,Cornelis J. A. Punt,Nicole C.T. van Grieken,Remond J.A. Fijneman,Gerrit A. Meijer,Hatim Husain,Robert B. Scharpf,Luis A. Diaz,Siân Jones,Samuel V. Angiuoli,Torben F. Ørntoft,Hans Jørgen Nielsen,Claus L. Andersen,Victor E. Velculescu +36 more
TL;DR: In patients with resectable colorectal cancers, higher amounts of preoperative circulating tumor DNA were associated with disease recurrence and decreased overall survival, and a method developed by Phallen et al., called targeted error correction sequencing, demonstrates the feasibility of detecting circulating cell-free DNA from many early tumors, suggesting its potential use for cancer screening.
Journal ArticleDOI
Genome-wide cell-free DNA fragmentation in patients with cancer
Stephen Cristiano,Alessandro Leal,Jillian Phallen,Jacob Fiksel,Vilmos Adleff,Daniel C. Bruhm,Sarah Østrup Jensen,Jamie E. Medina,Carolyn Hruban,James R. White,Doreen N. Palsgrove,Noushin Niknafs,Valsamo Anagnostou,Patrick M. Forde,Jarushka Naidoo,Kristen A. Marrone,Julie R. Brahmer,Brian Woodward,Hatim Husain,Karlijn L. van Rooijen,Mai Britt Worm Ørntoft,Anders Husted Madsen,Cornelis J.H. van de Velde,Marcel Verheij,Annemieke Cats,Cornelis J. A. Punt,Geraldine R. Vink,Nicole C.T. van Grieken,Miriam Koopman,Remond J.A. Fijneman,Julia S. Johansen,Hans Jørgen Nielsen,Gerrit A. Meijer,Claus L. Andersen,Robert B. Scharpf,Victor E. Velculescu +35 more
TL;DR: An approach to evaluate fragmentation patterns of cell-free DNA across the genome was developed, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered fragmentation profiles.
Journal ArticleDOI
Diagnostic and Prognostic MicroRNAs in Stage II Colon Cancer
Troels Schepeler,Jørgen Thomas Reinert,Marie Stampe Ostenfeld,Lise Lotte Christensen,Asli Silahtaroglu,Lars Dyrskjøt,Carsten Wiuf,Frank J. Sørensen,Mogens Kruhøffer,Søren Laurberg,Sakari Kauppinen,Torben F. Ørntoft,Claus L. Andersen +12 more
TL;DR: The results suggest that perturbed expression of numerous miRNAs in colon cancer may have a functional effect on tumor cell behavior, and, furthermore, that some miRNAAs with prognostic potential could be of clinical importance.