M
Matthias Dreyer
Publications - 1
Citations - 87
Matthias Dreyer is an academic researcher. The author has contributed to research in topics: Ectodomain & Insulin receptor. The author has an hindex of 1, co-authored 1 publications receiving 50 citations.
Papers
More filters
Journal ArticleDOI
The signalling conformation of the insulin receptor ectodomain.
Felix Weis,John G. Menting,Mai B. Margetts,Shu Jin Chan,Yibin Xu,Yibin Xu,Norbert Tennagels,Paulus Wohlfart,Thomas Langer,Christoph W. Müller,Matthias Dreyer,Michael C. Lawrence,Michael C. Lawrence +12 more
TL;DR: The structure reveals how the membrane proximal domains of the receptor come together to effect signalling and how insulin’s negative cooperativity of binding likely arises and provides insight into the high affinity of certain super-mitogenic insulins.