John G. Menting

TL;DR: In this paper, the authors show that the amino acid differences in the enzyme dihydropteroate synthase (DHPS) enzyme of sulfadoxine-resistant isolates of P. falciparum are central to resistance to sulfones and sulfonamides.

TL;DR: The first view, to the authors' knowledge, of the interaction of insulin with its primary binding site on the insulin receptor is presented, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs, providing an explanation for a wealth of biochemical data from the insulin receptors and IGF1R systems relevant to the design of therapeutic insulin analogues.

TL;DR: Restriction-fragment length polymorphism mapping and complementation of mutant petunia lines showed that the flavonoid 3',5'-hydroxylase genes correspond to the genetic loci Hfl and Hf2.

TL;DR: A model is proposed for Thyroxine transport from the bloodstream into cerebrospinal fluid based on partitioning of thyroxine between choroid plexus and surrounding fluids and binding of thyoxine to transthyretin newly synthesized and secreted by choroids plexi.

TL;DR: A conformational switch that enables otherwise hidden nonpolar surfaces in the hormone to engage its receptor is described, envisaging that a switch between free and receptor-bound conformations of insulin evolved as a solution to conflicting structural determinants of biosynthesis and function.