Matthias P.A. Ebert

TL;DR: A sieving strategy for identifying high-performing marker assays that detect colorectal cancer-specific methylated DNA in plasma and stringent criteria applied at all steps of the selection and validation process enabled successful identification and ranking of blood-based marker candidates.

TL;DR: High HDAC expression is significantly associated with nodal spread and is an independent prognostic marker for gastric cancer, and it is postulate that immunohistochemical detection of HDAC as a companion diagnostic method might predict treatment response to HDIs, thereby enabling selection of patients for this specific targeted treatment in Gastric cancer.

TL;DR: MALDI imaging in combination with hierarchical clustering allows the comprehensive analysis of the in situ cancer proteome in complex human cancers and opens the way for specific and cancer-related in situ biomarker analysis and identification.

TL;DR: In this paper, the authors used Matrix-Aided Laser Desorption/ionization (MALDI) imaging mass spectrometry (IMS) to determine HER2 status directly from breast cancer tissues.

TL;DR: Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9.