M
Mattias Enoksson
Researcher at Karolinska University Hospital
Publications - 20
Citations - 828
Mattias Enoksson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Mast cell & Interleukin 33. The author has an hindex of 13, co-authored 20 publications receiving 750 citations. Previous affiliations of Mattias Enoksson include Uppsala University & Karolinska Institutet.
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Journal ArticleDOI
Mast cells as sensors of cell injury through IL-33 recognition.
Mattias Enoksson,Katarina Lyberg,Christine Möller-Westerberg,Padraic G. Fallon,Gunnar Nilsson,Carolina Lunderius-Andersson +5 more
TL;DR: It is demonstrated that mast cells, potent promoters of acute inflammation, play a key role in responding to cell injury by recognizing IL-33 released from necrotic structural cells, thus providing novel insights concerning the role of mast cells as sensors of cell injury.
Journal ArticleDOI
The Extended Cleavage Specificity of Human Thrombin
TL;DR: Interestingly, no natural substrates display the obtained consensus sequence but represent sequences that show only 1–30% of the optimal cleavage rate for thrombin, which clearly indicates that maximal cleavage, excluding the help of exosite interactions, is not always desired, which may instead cause problems with dysregulated coagulation.
Journal ArticleDOI
Intraperitoneal influx of neutrophils in response to IL-33 is mast cell–dependent
Mattias Enoksson,Christine Möller-Westerberg,Grzegorz Wicher,Padraic G. Fallon,Karin Forsberg-Nilsson,Carolina Lunderius-Andersson,Gunnar Nilsson +6 more
TL;DR: It is found that wild-type mice, but not mast cell-deficient W(sh)/W(sh) mice, respond to IL-33 treatment with neutrophil infiltration to the peritoneum, whereas other investigated cell types remained unchanged.
Journal ArticleDOI
Mast cells respond to cell injury through the recognition of IL-33
TL;DR: The function of mast cells as sentinel cells in the context of cell injury, where mast cells respond by initiating an inflammatory response to IL-33 has turned out to be of particular interest.
Journal ArticleDOI
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.
TL;DR: It is shown that a rather stringent chymotryptic substrate recognition profile has been evolutionary conserved for the dominant CTMC chymase in mammals.