Mauro Colafranceschi

TL;DR: This study confirmed the association between MSI and favourable prognosis as determined by both OS and DFS of CRC patients and proposed that this inconclusive result is due to the use of a single marker, such as MSI, that cannot account alone for the complexity of the mechanisms underlying 5-FU cytotoxicity.

TL;DR: In this paper, a global complexity score for numerical series is derived from principal components analysis of a group of nonlinear measures of experimental as well simulated series, and the concept of complexity is demonstrated to be independent from other descriptors of ordered series such as the amount of variance, the departure from normality and the relative nonstationarity; and mainly related to the number of independent elements (or operations) needed to synthesize the series.

TL;DR: The most deterministic proteins in terms of autocorrelation properties of primary structures were found to be involved in protein-protein and protein-DNA interactions and to display a significantly higher proportion of structural disorder with respect to the average data set.

TL;DR: This chapter, after a general overview of traditional and well-known approaches, gives a detailed presentation of the latter more recent support tools freely available in the public domain.

TL;DR: To better understand the strength of the SAR science in OncoLogic®, a select group of modulating factors on the predictions by the structural alerts were investigated.