M
Max S. Topp
Researcher at Fred Hutchinson Cancer Research Center
Publications - 5
Citations - 1253
Max S. Topp is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: T cell & Natural killer T cell. The author has an hindex of 5, co-authored 5 publications receiving 1210 citations.
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Journal ArticleDOI
Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.
Veronika Groh,Rebecca Rhinehart,Julie Randolph-Habecker,Max S. Topp,Stanley R. Riddell,Thomas Spies +5 more
TL;DR: Infection by cytomegalovirus resulted in substantial increases in MIC on cultured fibroblast and endothelial cells and was associated with induced MIC expression in interstitial pneumonia, and NKG2D functioned as a costimulatory receptor that can substitute for CD28.
Journal ArticleDOI
Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production.
Max S. Topp,Stanley R. Riddell,Stanley R. Riddell,Yoshiki Akatsuka,Michael C. Jensen,Joseph N. Blattman,Joseph N. Blattman,Philip D. Greenberg,Philip D. Greenberg +8 more
TL;DR: The results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8- T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8 + T cells.
Journal ArticleDOI
Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus
David M. Koelle,Zhi Liu,Christopher M. McClurkan,Max S. Topp,Stanley R. Riddell,Eric G. Pamer,Andrew S. Johnson,Anna Wald,Lawrence Corey +8 more
TL;DR: This is the first report of expression of tissue-specific adhesion-associated molecules by virus-specific CD8(+) T cells, consistent with a role for CLA in skin homing in HSV-2-infected skin.
Journal Article
Immunotherapy of human viral and malignant diseases with genetically modified T-cell clones
Stanley R. Riddell,Edus H. Warren,Marc A. Gavin,Yoshiki Akatsuka,Deborah A. Lewinsohn,Helen Mutimer,Laurence J.N. Cooper,Max S. Topp,Chiara Bonini,Philip D. Greenberg +9 more
Book ChapterDOI
Application of T cell immunotherapy for human viral and malignant diseases.
Stanley R. Riddell,Edus H. Warren,Deborah A. Lewinsohn,Helen Mutimer,Max S. Topp,Laurence J.N. Cooper,R. de Fries,Phil Greenberg +7 more
TL;DR: The early results of clinical studies of T cell therapy for viral diseases have been encouraging and this approach is now being developed for the treatment of patients with leukemia that recurs after allogeneic bone marrow transplant (BMT) and patients with solid tumors.