Mazyar Barekati-Mowahed

TL;DR: The evolutionary origins, basic architectures, and molecular mechanisms of Cpf1 family proteins, as well as crRNA designing and delivery strategies are discussed, which have broadened the versatility and feasibility of this system in genome editing, transcription regulation, epigenetic modulation, and base editing.

TL;DR: Pre-clinical data and clinical trial data on 17-DMAG as a single agent, in combination with other agents and loaded on nanomaterials in various cancers and inflammatory diseases are reviewed.

TL;DR: The challenges of diagnostic CRISPR based platforms as well as clarifying the proposed solution for high efficient selective in vivo delivery ofCRISPR components into SARS-CoV-2-infected cells are discussed.

TL;DR: The structure, function, and development in genome editing mediated by CRISP/Cas9 system is discussed, and the genes involved in the pathogenesis of PD and the pertinent alterations to them are described.

TL;DR: It is concluded that Ang-1 potentially induces functional and mature vascular-like behavior in EPCs more than Ang-2 and that Tie-2 plays a key role on angiogenesis pathways in endothelial lineage cells.