M
Mee Kian Poh
Researcher at Novartis Institute for Tropical Diseases
Publications - 4
Citations - 554
Mee Kian Poh is an academic researcher from Novartis Institute for Tropical Diseases. The author has contributed to research in topics: Dengue virus & Antibody-dependent enhancement. The author has an hindex of 4, co-authored 4 publications receiving 507 citations. Previous affiliations of Mee Kian Poh include Novartis.
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Journal ArticleDOI
A Small-Molecule Dengue Virus Entry Inhibitor
Qing-Yin Wang,Sejal J. Patel,Eric Vangrevelinghe,Hao Ying Xu,Ranga Rao,Deana Jaber,Wouter Schul,Feng Gu,Olivier Heudi,Ngai Ling Ma,Mee Kian Poh,Wai Yee Phong,Thomas H. Keller,Edgar Jacoby,Subhash G. Vasudevan +14 more
TL;DR: Compound 6 was identified as one of the inhibitors and had an average 50% effective concentration of 119 nM against dengue virus serotype 2 in a human cell line and Mechanism-of-action studies demonstrated that compound 6 acts at an early stage during d Dengue virus infection.
Journal ArticleDOI
Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis
Qing Yin Wang,Bushell Simon,Min Qing,Hao Ying Xu,Aurelio Bonavia,Sandra Nunes,Jing Zhou,Mee Kian Poh,Paola Florez de Sessions,Pornwaratt Niyomrattanakit,Hongping Dong,Keith Hoffmaster,Anne Goh,Shahul Nilar,Wouter Schul,Susan Jones,Laura D. Kramer,Teresa Compton,Pei Yong Shi +18 more
TL;DR: A novel antiviral compound (NITD-982) that inhibits host dihydroorotate dehydrogenase (DHODH), an enzyme required for pyrimidine biosynthesis is reported, demonstrating that the compound inhibits DENV through depleting the intracellular pyridine pool.
Journal ArticleDOI
A small molecule fusion inhibitor of dengue virus.
Mee Kian Poh,Andy Yip,Summer L. Zhang,John P. Priestle,Ngai Ling Ma,Jolanda M. Smit,Jan Wilschut,Pei Yong Shi,Markus R. Wenk,Wouter Schul +9 more
TL;DR: The in silico virtual screening for small molecules that can potentially bind to the betaOG pocket and tested these candidate molecules in the two fusion assays identified one compound that inhibits dengue fusion in both assays, in agreement with a mechanism of action through fusion inhibition.
Journal ArticleDOI
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.
TL;DR: It is shown that dengue virus infection was affected when the cholesterol intake in infected cells was disrupted using a cholesterol transport inhibitor, U18666A, suggesting d Dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication.